Stephen C Wilkie

US Patent:

6509331, Jan 21, 2003

Filed:

Jun 21, 1999

Appl. No.:

09/337484

Inventors:

James E. Audia - Indianapolis IN
Richard C. Thompson - Frankfort IN
Stephen C. Wilkie - Indianapolis IN
Thomas C. Britton - Carmel IN
Warren J. Porter - Indianapolis IN
George W. Huffman - Carmel IN
Lee H. Latimer - Oakland CA

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
Eli Lilly Company - Indianapolis IN

International Classification:

C07D48700

US Classification:

51421204, 51421207, 540522, 540523

Abstract:

Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.

US Patent:

6552013, Apr 22, 2003

Filed:

Jun 22, 1999

Appl. No.:

09/338121

Inventors:

James E. Audia - Indianapolis IN
Warren J. Porter - Indianapolis IN
Richard C. Thompson - Frankfort IN
Stephen C. Wilkie - Indianapolis IN
Douglas R. Stack - Fishers IN
Qing Shi - Carmel IN

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
Eli Lilly and Company - Indianapolis IN

International Classification:

C07D24324

US Classification:

51421204, 51421207, 540522, 540523

Abstract:

Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.

US Patent:

6569851, May 27, 2003

Filed:

Jun 22, 1999

Appl. No.:

09/338191

Inventors:

Richard C. Thompson - Frankfort IN
Stephen Wilkie - Indianapolis IN
Douglas R. Stack - Fishers IN
Eldon E. VanMeter - Greenwood IN
Qing Shi - Carmel IN
Thomas C. Britton - Carmel IN
James E. Audia - Indianapolis IN
Jon K. Reel - Carmel IN
Thomas E. Mabry - Indianapolis IN
Bruce A. Dressman - Indianapolis IN
Cynthia L. Cwi - Indianapolis IN
Steven S. Henry - New Palestine IN
Stacey L. McDaniel - Martinsville IN
Russell D. Stucky - Indianapolis IN
Warren J. Porter - Indianapolis IN

Assignee:

Elan Pharmaceutials, Inc. - South San Francisco CA
Eli Lilly Company - Indianapolis IN

International Classification:

C07D24324

US Classification:

514219, 514220, 514221, 540509, 540517, 540518, 540558, 540559, 540560, 540561

Abstract:

Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.

US Patent:

6670446, Dec 30, 2003

Filed:

Sep 26, 2000

Appl. No.:

09/647113

Inventors:

Richard Craig Thompson - Frankfort IN
Stephen Charles Wilkie - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07K 750

US Classification:

530317, 514 8, 514 11, 530322

Abstract:

Described herein are Nâ-acylated derivatives of desleucylA82846B. The compounds are useful as antibacterial agents.

US Patent:

6774125, Aug 10, 2004

Filed:

Oct 7, 2002

Appl. No.:

10/267017

Inventors:

James E. Audia - Indianapolis IN
Richard C. Thompson - Frankfort IN
Stephen C. Wilkie - Indianapolis IN
Thomas C. Britton - Carmel IN
Warren J. Porter - Indianapolis IN
George W. Huffman - Carmel IN
Lee H. Latimer - Oakland CA

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
Eli Lilly Company - Indianapolis IN

International Classification:

C07D24312

US Classification:

514220, 514221, 540496, 540497, 540498, 540499, 540504, 540517, 540518

Abstract:

Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.

US Patent:

6838455, Jan 4, 2005

Filed:

Dec 23, 2002

Appl. No.:

10/326081

Inventors:

James E. Audia - Indianapolis IN, US
Warren J. Porter - Indianapolis IN, US
Richard C. Thompson - Frankfort IN, US
Stephen C. Wilkie - Indianapolis IN, US
Douglas R. Stack - Fishers IN, US
Qing Shi - Carmel IN, US

Assignee:

Athena Neurosciences, Inc. - South San Francisco CA
Eli Lilly & Company - Indianapolis IN

International Classification:

C07D48700
C07D49100
C07D48704
C07D24312
A61K 3155

US Classification:

514220, 514221, 540496, 540497, 540498, 540499, 540504, 540517, 540518

Abstract:

Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

US Patent:

6906056, Jun 14, 2005

Filed:

Mar 20, 2003

Appl. No.:

10/392332

Inventors:

Richard C. Thompson - Frankfort IN, US
Stephen Wilkie - Indianapolis IN, US
Douglas R. Stack - Fishers IN, US
Eldon E. Vanmeter - Greenwood IN, US
Qing Shi - Carmel IN, US
Thomas C. Britton - Carmel IN, US
James E. Audia - Indianapolis IN, US
Jon K. Reel - Carmel IN, US
Thomas E. Mabry - Indianapolis IN, US
Bruce A. Dressman - Indianapolis IN, US
Cynthia L. Cwi - Indianapolis IN, US
Steven S. Henry - New Palestine IN, US
Stacey L. McDaniel - Martinsville IN, US
Russell D. Stucky - Indianapolis IN, US
Warren J. Porter - Indianapolis IN, US

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
Eli Lilly & Company - Indianapolis IN

International Classification:

C07D267/02
C07D487/00
C07D223/12
A61K031/55
A61P025/28

US Classification:

51421106, 51421203, 51421204, 51421207, 540491, 540522, 540523, 540527

Abstract:

Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

US Patent:

6939947, Sep 6, 2005

Filed:

Nov 18, 2003

Appl. No.:

10/717163

Inventors:

Richard Craig Thompson - Frankfort IN, US
Stephen Charles Wilkie - Indianapolis IN, US

Assignee:

InterMune, Inc. - Brisbane CA

International Classification:

C07K007/50

US Classification:

530317, 530322, 514 8, 514 11

Abstract:

The present invention is directed to N-acylated derivatives of desleucylA82846B. These derivatives are useful as antibacterials.