Steven Jules Ackerman - Naperville IL, US Fan Gao Laffey - Chicago IL, US Ben Hitchinson - Chicago IL, US Boris Garnier - Chatanay-malabry, FR Vadim Gaponenko - Naperville IL, US Nadya Tarasova - Frederick MD, US Hazem Abdelkarim - Worth IL, US
International Classification:
A61K 38/19 A61K 47/68 A61K 47/10 C07K 14/52
Abstract:
A C—C chemokine receptor 3 (CCR3) peptide analog that exhibits biased antagonism by binding to and inhibiting ligand-mediated signaling and chemotaxis while promoting the internalization and degradation of CCR3 is provided as is a method of using the peptide analog to treat, prevent, or ameliorate one or more symptoms of an eosinophil- or CCR3-mediated disease or condition.
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