Steven E Dunlap

US Patent:

6426417, Jul 30, 2002

Filed:

Aug 2, 2000

Appl. No.:

09/601707

Inventors:

Charles Jackson Barnett - Indianapolis IN
Steven Eugene Dunlap - Fishers IN
Michael Edward Kobierski - Greenwood IN
John Arnold Werner - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D47102

US Classification:

544279

US Patent:

61143278, Sep 5, 2000

Filed:

Oct 22, 1999

Appl. No.:

9/425093

Inventors:

Steven Eugene Dunlap - Fishers IN
Louis Nickolaus Jungheim - Indianapolis IN
Mark Joseph Tebbe - Indianapolis IN
Gilbert Thomas Voy - Indianapolis IN
John Arnold Werner - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 314184
A61K 31541
A61K 315377
C07D23530
C07D41704

US Classification:

5142272

Abstract:

The present application provides a series of benzimidazole compounds of formula I: ##STR1## which inhibit the growth of picornaviruses, such as rhinoviruses (bovine and human), enteroviruses such as polioviruses, coxsackieviruses of the A and B groups, or echo virus, cardioviruses such as encephalomyocarditis (EMC), apthoviruses such as foot and mouth disease virus, and flaviviruses such as hepatitis C virus and bovine viral diarrhea virus. Such compounds are also useful as intermediates for preparing additional benzimidazole antiviral compounds.