Steven A Goldstein

US Patent:

8417322, Apr 9, 2013

Filed:

Jun 29, 2004

Appl. No.:

10/879797

Inventors:

Michael D. Morris - Ann Arbor MI, US
Steven A. Goldstein - Ann Arbor MI, US
Barbara R. McCreadie - Ann Arbor MI, US
Tso-Ching Chen - Ann Arbor MI, US

Assignee:

Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61B 5/00

US Classification:

600477

Abstract:

In a method for diagnosing or helping to diagnose a bone tissue condition of a patient, a portion of bone tissue of the patient is irradiated using a light source. The bone tissue may be irradiated in vivo through the skin or via an incision, for example. Alternatively, a biopsy of the bone tissue may be irradiated. Then, spectral content information for light scattered, reflected, or transmitted by the bone tissue is determined, and is used, at least in part, to determine whether the patient has a bone tissue condition.

US Patent:

20020193338, Dec 19, 2002

Filed:

Jun 20, 2002

Appl. No.:

10/177680

Inventors:

Steven Goldstein - Ann Arbor MI, US
Jeffrey Bonadio - Ann Arbor MI, US

International Classification:

A61K048/00

US Classification:

514/044000, 424/423000

Abstract:

The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.

US Patent:

20050119587, Jun 2, 2005

Filed:

Sep 17, 2004

Appl. No.:

10/944518

Inventors:

Blake Roessler - Ann Arbor MI, US
Michael Morris - Ann Arbor MI, US
Steven Goldstein - Ann Arbor MI, US
Abigail Smukler - Ann Arbor MI, US
Nicole Crane - Ypsilanti MI, US
Barbara McCreadie - Ann Arbor MI, US
Tso-Ching Chen - Whitmore Lake MI, US

Assignee:

UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

A61B010/00

US Classification:

600562000

Abstract:

In a method for evaluating a connective tissue condition of a patient, an indicator of the supporting tissue condition may be generated. A portion of connective tissue of the patient is irradiated using a light source. The connective tissue may be irradiated in vivo through the skin or via an incision, for example. Alternatively, a biopsy of the connective tissue may be irradiated. Then, spectral content information for light scattered, reflected, or transmitted by the connective tissue is determined. The spectral content information is used, at least in part, to generate the indicator. The indicator may assist a physician in diagnosing or ruling out the connective tissue condition, determining a risk of developing a disease, monitoring the progression of a disease, monitoring a response to treatment, etc.

US Patent:

20060035854, Feb 16, 2006

Filed:

Feb 28, 2005

Appl. No.:

11/068735

Inventors:

Steven Goldstein - Ann Arbor MI, US
Robert Levy - Ann Arbor MI, US
Vinod Labhasetwar - Ann Arbor MI, US
Jeffrey Bonadio - Ann Arbor MI, US

International Classification:

A61K 48/00
A61K 9/14
A61L 9/04

US Classification:

514044000, 424045000, 424046000

Abstract:

The present invention provides compositions and methods for coating medical devices with pharmaceutical agents and devices coated with the compositions. The coated devices provide controlled or sustained release of pharmaceutical agents for the treatment of wounds or disease.

US Patent:

20090198184, Aug 6, 2009

Filed:

Feb 5, 2009

Appl. No.:

12/322716

Inventors:

David C. Martin - Ann Arobor MI, US
Antonio Peramo - Ann Arbor MI, US
Steven A. Goldstein - Ann Arbor MI, US

International Classification:

A61M 5/00
A61M 1/00
A61M 25/14
A61B 17/60
A61B 17/58
A61B 17/70
A61F 2/82
A61F 2/18
A61F 2/60
A61F 2/54

US Classification:

604151, 60428804, 604523, 604264, 606 54, 606 53, 606246, 623 115, 623 10, 623 27, 623 57

Abstract:

A percutaneous biomedical device comprising a body having a lumen extending longitudinally at least partially through the body, an implantable interface region disposed on the body, the implantable interface region having a plurality of radially extending conduits through the body, each of the conduits are in fluid communication with the lumen and in fluid communication with an exit port. The exit ports extrude a skin-interface composition between the subject's skin and the percutaneous biomedical device. Methods for implanting a percutaneous biomedical device includes implanting a percutaneous biomedical device percutaneously in a subject and aligning the exit ports of the implantable interface region between the epidermis and the hypodermis skin layers of the subject.

US Patent:

20100189792, Jul 29, 2010

Filed:

Jan 26, 2009

Appl. No.:

12/360056

Inventors:

Steven A. Goldstein - Ann Arbor MI, US
Jeffrey Bonadio - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

A61K 31/7088
A61K 9/14
A61P 17/02

US Classification:

424484, 514 44 R

Abstract:

The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.

US Patent:

20110009283, Jan 13, 2011

Filed:

Dec 5, 2008

Appl. No.:

12/746410

Inventors:

Steven A. Goldstein - Chicago IL, US
Zoltan Takacs - Chicago IL, US

International Classification:

C40B 30/04
G01N 33/53
C40B 40/10
C07K 14/00

US Classification:

506 9, 436501, 506 18, 530324

Abstract:

The disclosure relates to a method and system of screening for ligands which specifically bind to receptors. The method comprises expressing at least one receptor. The at least one receptor is contacted with a sample comprising at least one ligand. Whether the ligand selectively binds to the receptor is determined.

US Patent:

20120100107, Apr 26, 2012

Filed:

Jan 10, 2012

Appl. No.:

13/347451

Inventors:

Steven A. Goldstein - Ann Arbor MI, US
Jeffrey Bonadio - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61K 31/7088
A61P 17/02

US Classification:

424 932, 514 44 R

Abstract:

The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.