Steven M Goodman

US Patent:

7087228, Aug 8, 2006

Filed:

Jul 2, 2003

Appl. No.:

10/614072

Inventors:

Steven D. Goodman - Redondo Beach CA, US
Olga Kay - Los Angeles CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 39/40
C07H 21/04
C07K 16/00

US Classification:

4241651, 536 237, 5303884

Abstract:

The present invention provides compositions, medicaments, and methods for the treatment or prophylaxis of conditions associated with the binding of to teeth. Specifically, the present invention provides a method for preventing dental caries and infective endocarditis in a subject by treating the subject's oral cavity with a composition or medicament comprising the competence stimulating peptide (CSP) of the causative bacterium, which inhibits the ability of the said bacteria to attach to the surface of teeth. Novel anti-caries compositions using the CSP are also disclosed.

US Patent:

20070298060, Dec 27, 2007

Filed:

Jun 8, 2007

Appl. No.:

11/760626

Inventors:

Steven Goodman - Redondo Beach CA, US
Jennifer Downey - Simi Valley CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 8/02
A47L 23/02
A61K 9/68
A61P 1/02
A61K 8/00

US Classification:

424401000, 015028000, 424440000, 424049000

Abstract:

Herein is provided a method for treating or preventing caries by applying a caries-causing agent removal device, a device capable of selectively and preferentially binding the caries-causing agent compare with other surrounding non-cariogenic organisms. There is also provided a set of compounds for formulating the device thereof. Exemplary compounds include glycosidic polymers such as Sephadex. Specific examples of a device of the present invention include candy, chewing gums, mouthwash, and toothpaste

US Patent:

20080069782, Mar 20, 2008

Filed:

Nov 17, 2006

Appl. No.:

11/561275

Inventors:

Steven D. GOODMAN - Redondo Beach CA, US
Olga Kay - Los Angeles CA, US
Wenyuan Shi - Los Angeles CA, US
Fengxia Ql - Oklahoma City OK, US

International Classification:

A61K 8/18
A61K 8/21
A61K 8/40
A61K 8/55
A61Q 11/00
C12N 1/00

US Classification:

424 52, 424 49, 424 54, 424 57, 435243

Abstract:

Methods for selectively manipulating a growth rate of a selected bacterium comprising the step of contacting the selected bacterium with a predetermined amount of a quorum sensing molecule to affect a change in the growth rate of the selected bacterium, wherein the quorum sensing molecule is species specific, and the change in the growth rate is dependent on the amount of quorum sensing molecule in a dose-dependent fashion. Also provided are methods for treating or protecting against bacterial infections by utilizing the dose-dependent response of bacterial quorum sensing systems. The methods can be applied to a wide range of bacteria species including , and . Compositions, medicaments and oral formulations for use with the methods are also disclosed.

US Patent:

20110236306, Sep 29, 2011

Filed:

Mar 28, 2011

Appl. No.:

13/073782

Inventors:

STEVEN D. GOODMAN - LOS ANGELES CA, US
LAUREN O. BAKALETZ - COLUMBUS OH, US

International Classification:

A61K 49/16
A01N 37/18
A61K 31/7088
A61K 39/40
A61K 39/00
A61K 38/46
A61K 39/02
A61K 39/108
G01N 33/566
A61K 38/02
A01N 57/16
A61K 39/395
C07K 7/06
C07K 7/08
C07H 21/00
C12N 15/63
C12N 5/10
C12N 1/00
C12N 5/078
C07K 16/12
C07K 16/46
C12N 5/16
C40B 30/04
A61P 31/00
A01P 1/00
A61P 31/04
A61P 37/04
G06G 7/60

US Classification:

424 149, 514 23, 514 44 R, 4241691, 4241391, 4241641, 4241331, 4241781, 4241341, 4241841, 424 946, 4242341, 4242571, 4241901, 436501, 4241301, 530328, 530329, 530327, 530326, 536 237, 4353201, 435325, 435243, 5303879, 5303873, 5303913, 5303917, 435331, 4241501, 506 9, 703 11

Abstract:

This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system.

US Patent:

20120128701, May 24, 2012

Filed:

Sep 9, 2011

Appl. No.:

13/229575

Inventors:

Steven D. Goodman - Los Angeles CA, US
Lauren O. Bakaletz - Columbus OH, US

International Classification:

A61K 38/17
A01P 1/00
A61P 31/04
A61K 39/00
A01N 37/46

US Classification:

4241841, 514 27, 514 26, 514 28, 514 24

Abstract:

Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more HMG-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.