Steven V Grant

US Patent:

20060110376, May 25, 2006

Filed:

Jun 22, 2005

Appl. No.:

11/158743

Inventors:

Paul Fisher - Scarsdale NY, US
Rahul Gopalkrishnan - New York NY, US
Irina Lebedeva - Bronx NY, US
Steven Grant - Richmond VA, US
Adly Yacoub - Richmond VA, US
Paul Dent - Glen Allen VA, US

International Classification:

A61K 48/00

US Classification:

424093210, 514044000

Abstract:

The present invention relates to methods of treating a cancer in a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. The present invention further relates to methods of inhibiting proliferation or promoting death in a cancer cell of a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. Generation of an effective amount of MDA-7 can occur by administering to the cancer cell an effective amount of an mda-7 nucleic acid, MDA-7 protein, functional equivalents of either of these molecules, by upregulation of the endogenous mda-7 gene, or by stabilization of the mda-7 mRNA. Generation of one or more free radicals in a cancer cell can occur by exposing the cancer cell to an effective amount of ionizing radiation, a free radical, a generator of a free radical, a ROS, a generator of a ROS, or a disruptor of mitochondrial membrane potential.