Steven J Hobbs

US Patent:

6867857, Mar 15, 2005

Filed:

Oct 29, 2002

Appl. No.:

10/282392

Inventors:

Steven E. Hobbs - West Hills CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

G01N007/10
G01N021/05

US Classification:

356246, 25029595, 422 681

Abstract:

A flow cell for performing optical analysis of a fluid is provided. The flow cell comprises a monolithic cell housing that defines a detection chamber, fluid inlet and outlet ports and illumination and detection ports. Optical fibers are inserted in the illumination and detection ports, thereby forming substantially fluid-tight seals. A flow cell may be press-fit against a microfluidic device, with fluid sealing aided by O-rings.

US Patent:

6923907, Aug 2, 2005

Filed:

Feb 13, 2003

Appl. No.:

10/366985

Inventors:

Steven E. Hobbs - West hills CA, US
Matthew M. Gregori - Los Angeles CA, US
Christoph D. Karp - Pasadena CA, US
Jeffrey A. Koehler - Pasadena CA, US
Paren P. Patel - Sierra Madre CA, US
Joseph F. Covington - San Gabriel CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

B01D015/08

US Classification:

2101982, 210656, 422 70, 422100, 73 6152

Abstract:

Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits. One or more splitters may be provided to distribute slurry and/or mobile phase among multiple separation columns. In one embodiment, separation devices are substantially planar and fabricated with multiple device layers. Systems and methods employing slurry for packing separation devices are also provided.

US Patent:

6936167, Aug 30, 2005

Filed:

Oct 28, 2003

Appl. No.:

10/696354

Inventors:

Steven E. Hobbs - West Hills CA, US
Hau H. Duong - Pasadena CA, US
Scott G. Beach - Manhattan Beach CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

B01D015/08

US Classification:

2101982, 210656, 210143, 422 70, 422100

Abstract:

Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressure pumps and analyte detectors. The use of pressure fit interfaces allows the microfluidic cartridges to easily be removed and replaced within the instrument, either manually or robotically.

US Patent:

6939941, Sep 6, 2005

Filed:

Aug 27, 2002

Appl. No.:

10/228731

Inventors:

John Richard Gilmore - Crystal Lake IL, US
Keith Bradley Potts - Elgin IL, US
Steven John Hobbs - Woodstock IL, US
Marc Edward Halpern - Cherry Hill NJ, US
Thomas Dennis Mundle - Mandevill LA, US

Assignee:

Toray Fine Chemicals Co., Ltd.

International Classification:

C08G075/14

US Classification:

528389, 528387, 528373, 528377, 528482, 528486, 568 21

Abstract:

A process is provided for the manufacture of liquid polysulfide polymers. In particular, the process allows for making the liquid form of the polysulfide polymer directly and eliminates the need to first make a solid polysulfide polymer and then convert it to a liquid.

US Patent:

6976384, Dec 20, 2005

Filed:

Oct 30, 2003

Appl. No.:

10/699533

Inventors:

Steven E. Hobbs - West Hills CA, US
Hau H. Duong - Pasadena CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

G01N030/00

US Classification:

73 6158, 73 6152

Abstract:

High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomultiplier tube, a charge-coupled device detector, a diode array, and a photodiode array. In certain embodiments, separation columns are microfluidic and integrated into a unitary microfluidic device. The optical path through a detection region is preferably coaxial with the path of eluate flow along a flow axis through a detection region. On-board or off-board detection regions may be provided.

US Patent:

6987263, Jan 17, 2006

Filed:

Dec 13, 2003

Appl. No.:

10/736154

Inventors:

Steven E. Hobbs - West Hills CA, US
Stephen D. O'Connor - Pasadena CA, US
Ronald C. Gamble - Altadena CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

B01D 54/44
H01J 49/00

US Classification:

250288, 250287

Abstract:

Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.

US Patent:

7045654, May 16, 2006

Filed:

Oct 21, 2003

Appl. No.:

10/691390

Inventors:

Steven J. Hobbs - Wolcott CT, US

Assignee:

Crompton Corporation - Middlebury CT

International Classification:

C07C 65/10

US Classification:

562477

Abstract:

A process is disclosed for the production of alkyl salicylic acids wherein the process comprises reacting salicylic acid with an olefin having at least four carbon atoms at elevated temperature in the presence of a perfluoroalkylsulfonic acid, an alkylsulfonic acid, or an acidic clay as a catalyst.

US Patent:

7145038, Dec 5, 2006

Filed:

Dec 14, 2005

Appl. No.:

11/304163

Inventors:

Steven J. Hobbs - Wolcott CT, US

Assignee:

Chemtura Corporation - Middlebury CT

International Classification:

C07C 2099/00

US Classification:

564409

Abstract:

A process for alkylation of a diphenylamine compound in an ionic liquid. The use of an ionic liquid permits convenient separation of the alkylated reaction product from the reaction mixture.