Steven R Marlin

US Patent:

6358510, Mar 19, 2002

Filed:

Jun 7, 1995

Appl. No.:

08/479763

Inventors:

Timothy A. Springer - Newton MA
Michael L. Dustin - University City MO
Robert Rothlein - Danbury CT
Steven D. Marlin - Danbury CT

Assignee:

Dana Farber Cancer Institute - Boston MA

International Classification:

A61K 3817

US Classification:

4241851, 4241841, 530300, 530350

Abstract:

The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.

US Patent:

7354588, Apr 8, 2008

Filed:

Jun 7, 1995

Appl. No.:

08/474388

Inventors:

Timothy A. Springer - Newton MA, US
Robert Rothlein - Danbury CT, US
Steven D. Marlin - Danbury CT, US
Michael L. Dustin - University City MO, US

Assignee:

Dana Farber Cancer Institute - Boston MA

International Classification:

A61K 38/17
A61K 38/16
C07K 14/435
C07K 14/705

US Classification:

4241851, 4241841, 514 2, 514 8, 530350, 530395

Abstract:

The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.

US Patent:

20090035321, Feb 5, 2009

Filed:

Dec 4, 2006

Appl. No.:

11/633078

Inventors:

Timothy A. Springer - Newton MA, US
Robert Rothlein - Danbury CT, US
Steven D. Marlin - Danbury CT, US
Michael L. Dustin - University City MO, US

International Classification:

A61K 39/395
C07K 14/47
C07H 21/04
C07K 1/22
C12Q 1/02

US Classification:

4241721, 530350, 536 235, 530413, 435 29

Abstract:

The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.

US Patent:

52849317, Feb 8, 1994

Filed:

Apr 27, 1990

Appl. No.:

7/515478

Inventors:

Timothy A. Springer - Newton MA
Robert Rothlein - Danbury CT
Steven D. Marlin - Danbury CT
Michael L. Dustin - University City MO

Assignee:

Dana Farber Cancer Institute - Boston MA

International Classification:

A61K 39395

US Classification:

424 858

Abstract:

Pharmaceutical compositions comprising antibodies to intercellular adhesion molecule-1 (ICAM-1 or CD54) are useful in methods of decreasing the severity of inflammation associated with the adhesion of leukocytes to cells bearing ICAM-1. Treatment with anti-ICAM-1 antibodies reduced the severity of inflammation associated with acute organ or tissue rejection and prolonged allograft survival time. Such compositions may optionally contain other immunsuppressive agents.

US Patent:

56122160, Mar 18, 1997

Filed:

Jan 25, 1994

Appl. No.:

8/186456

Inventors:

Timothy A. Springer - Newton MA
Robert Rothlein - Danbury CT
Steven D. Marlin - Danbury CT
Michael L. Dustin - University City MO

Assignee:

Dana Farber Cancer Institute - Boston MA

International Classification:

C12N 121
C12N 510
C12N 1512
C07K 14705

US Classification:

4352523

Abstract:

The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.

US Patent:

58310363, Nov 3, 1998

Filed:

Oct 25, 1993

Appl. No.:

8/140554

Inventors:

Timothy A. Springer - Newton MA
Robert Rothlein - Danbury CT
Steven D. Marlin - Danbury CT
Michael L. Dustin - University City MO

Assignee:

Dana Farber Cancer Institute - Boston MA

International Classification:

C07K 14705
A61K 3817

US Classification:

530395

Abstract:

The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.