Steven C Tannenbaum

US Patent:

6707035, Mar 16, 2004

Filed:

Aug 23, 2001

Appl. No.:

09/935909

Inventors:

Barbara J. Hughey - Lexington MA
Paul L. Skipper - Belmont MA
John S. Wishnok - Brookline MA
Ruth E. Shefer - Newton MA
John T. Mehl - South Boston MA
Steven R. Tannenbaum - Framingham MA

Assignee:

Newton Scientific, Inc. - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

H01J 4926

US Classification:

250288, 250423 R, 250282, 250281, 250423 P, 73 231

Abstract:

An interface system for introducing a non-gaseous sample as a predetermined gaseous form into an analytical instrument which comprises a substrate that receives the non-gaseous sample and a directed energy source that heats at least a portion of said substrate containing the non-gaseous sample to convert the sample to the predetermined gaseous form.

US Patent:

6867415, Mar 15, 2005

Filed:

Aug 23, 2001

Appl. No.:

09/938277

Inventors:

Barbara J. Hughey - Lexington MA, US
Paul L. Skipper - Belmont MA, US
John S. Wishnok - Boston MA, US
Ruth E. Shefer - Newton MA, US
Naomi A. Fried - Oakland CA, US
John T. Mehl - Westfield NJ, US
Steven R. Tannenbaum - Framingham MA, US

Assignee:

Newton Scientific, Inc. - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

H01J049/26

US Classification:

250288, 250288 A, 250282, 250423 R, 73 231

Abstract:

An interface for introducing a non-gaseous sample as a predetermined gaseous form into an accelerator mass spectrometer which comprises a nebulizer that receives the non-gaseous sample to provide a fine spray of the sample, a converter that receives at least a portion of said fine spray and converts the desired elements to the predetermined gaseous form and a flow line that transports the predetermined gaseous form to the accelerator mass spectrometer.

US Patent:

8318479, Nov 27, 2012

Filed:

May 19, 2005

Appl. No.:

11/133092

Inventors:

Karel Domansky - Cambridge MA, US
Linda G. Griffith - Cambridge MA, US
Steven R. Tannenbaum - Framingham MA, US
Alan Wells - Pittsburgh PA, US
Samuel Walker Inman - Boston MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Univeristy of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

C12M 1/22
C12M 3/00
C12M 1/34

US Classification:

4353052, 4353841, 4352873, 4352882, 4352883, 4352885, 4352931, 4353051, 4352991, 4353071

Abstract:

A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.

US Patent:

20060110826, May 25, 2006

Filed:

Jul 30, 2003

Appl. No.:

10/521920

Inventors:

John Leach - Roxbury Crossing MA, US
Steven Tannenbaum - Framingham MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12N 5/00
C12N 5/08

US Classification:

435370000, 435373000

Abstract:

The present invention provides methods for culturing primary hepatocytes with improved long term function and improved viability, by plating the hepatocytes in the presence of an anti-oxidants) as well as an agent(s) which is a functional inhibitor of enzymes that generate reactive oxygen and reactive nitrogen species. One preferred embodiment provides a combination of 2-oxo-thizolidine and tocopherol succinate. Another preferred embodiment provides a combination of N-methylarginine and mannitol.

US Patent:

20090137034, May 28, 2009

Filed:

Nov 24, 2008

Appl. No.:

12/276652

Inventors:

John K. Leach - Roxbury Crossing MA, US
Steven R. Tannenbaum - Framingham MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA

International Classification:

C12N 5/02

US Classification:

435325

Abstract:

The present invention provides methods for culturing primary hepatocytes with improved long term function and improved viability, by plating the hepatocytes in the presence of an anti-oxidant(s) as well as an agent(s) which is a functional inhibitor of enzymes that generate reactive oxygen and reactive nitrogen species. One preferred embodiment provides a combination of 2-oxo-thizolidine and tocopherol succinate. Another preferred embodiment provides a combination of N-methylarginine and mannitol.

US Patent:

54910684, Feb 13, 1996

Filed:

Dec 31, 1992

Appl. No.:

7/999363

Inventors:

Thomas L. Benjamin - Cambridge MA
Joan Chen-Wu - Brookline MA
Thomsen Hansen - Brookline MA
Barbara Jackson - Roslindale MA
David Livingston - Brookline MA
Steven Tannenbaum - Framingham MA
Gerald Wogan - Belmont MA

Assignee:

Vicam, L.P. - Watertown MA

International Classification:

G01N 3302
G01N 33538
G01N 33547
G01N 33569

US Classification:

435 732

Abstract:

An assay method is provided to easily and quickly detect the presence of organisms capable of being cultured, such as bacteria, characterized by antibody capture of the organism of interest by use of specialized magnetic beads, incubation of the captured cells to form colonies; removal of material from the colonies with a colony lift membrane; and detection of the colony material on the membrane sheet by use of labeled antibodies, PCR or nucleic acid probes.

US Patent:

56959460, Dec 9, 1997

Filed:

May 3, 1995

Appl. No.:

8/433076

Inventors:

Thomas L. Benjamin - Cambridge MA
Joan Chen-Wu - Brookline MA
Thomsen Hansen - Brookline MA
Barbara Jackson - Roslindale MA
David Livingston - Brookline MA
Steven Tannenbaum - Framingham MA
Gerald Wogan - Belmont MA

Assignee:

Vicam, LP - Sommerville MA

International Classification:

G01N 3302
G01N 33538
G01N 33547
G01N 33569

US Classification:

435 732

Abstract:

An assay method is provided to easily and quickly detect the presence of organisms capable of being cultured, such as bacteria, characterized by antibody capture of the organism of interest by use of specialized magnetic beads, incubation of the captured cells to form colonies; removal of material from the colonies with a colony lift membrane; and detection of the colony material on the membrane sheet by use of labeled antibodies, PCR or nucleic acid probes.

US Patent:

51399334, Aug 18, 1992

Filed:

Jun 25, 1990

Appl. No.:

7/542695

Inventors:

Calvert L. Green - Norfolk MA
Franz Fiedler - Munich, DE
Thomsen J. Hansen - Brookline MA
Gerald N. Wogan - Belmont MA
Steven R. Tannenbaum - Framingham MA
Thomas L. Benjamin - Cambridge MA

Assignee:

VICAM, L.P. - Somerville MA

International Classification:

G01N 33569

US Classification:

435732

Abstract:

An assay method is provided to quickly detect the presence of Listeria strains in samples, characterized by the use of antibodies to selectively capture the peptidoglycan and teichoic acid components of the listeriae bacterial cell wall.