A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.
This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.
Adel Youakim - Seattle WA, US Robert F. DuBose - Bellevue WA, US Steven R. Wiley - Seattle WA, US
Assignee:
Immunex Corporation - Thousand Oaks CA
International Classification:
C07K 1/00 G01N 33/53 A61K 38/00
US Classification:
530350, 435 71, 514 12
Abstract:
This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.
Compositions And Methods Relating To Multimeric And Oligomeric Soluble Fragments Of The Tweak Receptor
The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are useful for antagonizing the TWEAK receptor and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and inflammatory conditions.
Kristine M. Kim - Mill Creek WA, US Steven R. Wiley - Seattle WA, US Randal R. Ketchem - Snohomish WA, US
Assignee:
Immunex Corporation - Thousand Oaks CA
International Classification:
C07K 16/00
US Classification:
5303881, 5303913
Abstract:
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Name / Title
Company / Classification
Phones & Addresses
Steven Wiley Owner
Imdaptive Inc. Commercial Physical and Biological Research
3010 Nw 56Th St, Seattle, WA 98107
Steven Wiley Owner
Imdaptive Inc.
3010 NW 56 St, Seattle, WA 98107 (206)7349738
Steven Wiley Director
DRYER SOLUTIONS INC
17350 State Hwy 249 STE 220, Houston, TX 77064
Steven Wiley
Find Legal Paternity Test Infectious Disease Doctor
450 S Kitsap Blvd STE 202, Port Orchard, WA 98366 (888)5228386
Imdaptive since Oct 2008
Founder and President
VLST Mar 2004 - Sep 2008
Founder and CTO
Amgen 2003 - 2004
Scientist
Immunex 1993 - 2003
Senior Scientist
Abbott Laboratories 1996 - 1998
Scientist
Education:
University of Wisconsin-Madison 1987 - 1993
PhD., Cellular and Molecular biology
University of Chicago 1982 - 1986
B.S., Mathmatics
Skills:
Molecular Biology Protein Chemistry Biopharmaceuticals Drug Discovery Bioinformatics Biotechnology Immunology Technology Transfer Lifesciences Research Protein Purification Assay Development
David Kahn, Gianni Xeros, Casey Mock, Keisha Freeman, Travis Vandehey, Esther Mpyisi, Vincent Akinola, Ronald Johnson, Shannon Otoski, Bill Lonergan, Ricky Pace