Stuart Nelson Goodman

US Patent:

20090088846, Apr 2, 2009

Filed:

Apr 17, 2008

Appl. No.:

12/148534

Inventors:

David Myung - Santa Clara CA, US
Lampros Kourtis - Stanford CA, US
Laura Hartmann - San Francisco CA, US
Curtis W. Frank - Cupertino CA, US
Stuart B. Goodman - Los Altos CA, US
Dennis R. Carter - Stanford CA, US

International Classification:

A61F 2/08

US Classification:

623 1412, 424486, 424423, 424426

Abstract:

An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

US Patent:

20090227487, Sep 10, 2009

Filed:

Mar 4, 2009

Appl. No.:

12/397925

Inventors:

Jeremy Pearl - Stanford CA, US
Ting Ma - Stanford CA, US
William H. Robinson - Palo Alto CA, US
R. Lane Smith - Stanford CA, US
Stuart B. Goodman - Stanford CA, US

International Classification:

A61K 38/02
A61P 29/00

US Classification:

514 2

Abstract:

Particle induced inflammatory diseases are treated by administration of an effective dose of an inhibitor of MyD88 adaptor protein.

US Patent:

20120232657, Sep 13, 2012

Filed:

Mar 12, 2012

Appl. No.:

13/418294

Inventors:

David Myung - Santa Clara CA, US
Lampros Kourtis - Stanford CA, US
Laura Hartmann - San Francisco CA, US
Curtis W. Frank - Cupertino CA, US
Stuart B. Goodman - Los Altos CA, US
Dennis R. Carter - Stanford CA, US

International Classification:

A61F 2/02

US Classification:

623 1412

Abstract:

An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

US Patent:

62996495, Oct 9, 2001

Filed:

Jul 26, 1999

Appl. No.:

9/360926

Inventors:

Fu-Kuo Chang - Stanford CA
Hasan Yildiz - No. 19 G. O. P. Istanbul, TR
Stuart B. Goodman - Los Altos CA

International Classification:

A61F 236

US Classification:

623 2334

Abstract:

The present invention discloses a side-dependent prosthetic device. The side-dependent prosthetic device is a composite prosthetic device with a longitudinal direction. The composite prosthetic device includes a plurality of plies wherein each ply being composed of a plurality of reinforced fibers aligned in a ply orientational angle. theta. i relative to the longitudinal direction of the prosthetic device, where i=1,2,3,. . . ,N and N being the number of the plies. The plurality of plies are laminated together for forming the prosthetic device wherein the ply orientational angles being arranged such that. theta. 1+. theta. 2+. theta. 3+. . . +. theta. sub. N -0 thus forming an unbalanced composite prosthetic device. In another preferred embodiment, the ply orientational angles. theta. i forming a sequence which is represented by ((. theta. sup. 1 /. theta. sup. 2). sub. s). sub.

US Patent:

20200315801, Oct 8, 2020

Filed:

Jun 17, 2020

Appl. No.:

16/904408

Inventors:

- Stanford CA, US
Stuart B. Goodman - Los Altos CA, US
Yaser Shanjani - Milpitas CA, US
Chi-Chun Pan - Stanford CA, US

International Classification:

A61F 2/28

Abstract:

An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.

US Patent:

20190298774, Oct 3, 2019

Filed:

Apr 1, 2019

Appl. No.:

16/371371

Inventors:

- Stanford CA, US
Stuart B. Goodman - Los Altos CA, US
Everett Hurteau Meyer - Belmont CA, US
Magdiel Pérez Cruz - San Mateo CA, US

International Classification:

A61K 35/28
A61K 47/68
C07K 16/28
C07K 14/54
A61P 3/10

Abstract:

Mesenchymal stromal cells are engineered to express a chimeric antigen receptor (CAR), that specifically binds a marker of activated myeloid cells, including without limitation folate receptor beta; and are administered to an individual for treatment of inflammation at sites characterized by the presence of activated myeloid cells.

US Patent:

20190255151, Aug 22, 2019

Filed:

Oct 6, 2017

Appl. No.:

16/340319

Inventors:

- Stanford CA, US
Jukka PAJARINEN - Stanford CA, US
Stuart B. GOODMAN - Stanford CA, US

International Classification:

A61K 38/20
A61K 35/28
A61K 38/18
A61K 38/19
A61P 21/00
A61P 19/02
A61P 29/00
A61P 19/10
A61P 3/10
C12N 15/86
A61K 9/00

Abstract:

Provided are compositions and methods for production of anti-inflammatory cytokines, growth factors, or chemokines. Provided are nucleic acids (e.g., expression vectors) that include an NFκB inflammation response element operably linked to a nucleotide sequence encoding an anti-inflammatory cytokine (e.g., IL-4). In some cases, the nucleic acid is an expression vector selected from: a linear expression vector, a circular expression vector, a plasmid, and a viral expression vector. Also provided are cells (e.g., mesenchymal stem cells—MSCs) comprising a nucleic acid that includes an NFB inflammation response element operably linked to a nucleotide sequence encoding an anti-inflammatory cytokine. In some cases, the nucleic acid is integrated into the cell's genome. Also provided are methods for treating an individual having an inflammation-associated ailment, which can include administering an MSC to the individual, where the MSC includes an NFB inflammation response element operably linked to a nucleotide sequence encoding an anti-inflammatory cytokine.

US Patent:

20180043062, Feb 15, 2018

Filed:

Mar 18, 2016

Appl. No.:

15/559550

Inventors:

- Palo Alto CA, US
Stuart B. Goodman - Los Altos CA, US
Yaser Shanjani - Milpitas CA, US

International Classification:

A61L 27/58
A61L 27/18
A61F 2/36
A61L 27/12
A61L 27/54
A61L 27/56
A61L 27/10

Abstract:

An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.