- Duarte CA, US Qi Cui - Duarte CA, US Su Yang - San Diego CA, US
International Classification:
C12N 15/113 A01K 67/027 A61P 35/00 A61K 31/203
Abstract:
Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulation may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g., glioblastoma.
Targeting Glioblastoma Stem Cells Through The Tlx-Tet3 Axis
- Duarte CA, US Qi Cui - Duarte CA, US Su Yang - San Diego CA, US
International Classification:
C12N 15/113 A01K 67/027 A61P 35/00 A61K 31/203
Abstract:
Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulation may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g., glioblastoma.
Targeting Glioblastoma Stem Cells Through The Tlx-Tet3 Axis
- Duarte CA, US Qi Cui - Duarte CA, US Su Yang - San Diego CA, US
International Classification:
C12N 15/113 A61K 31/203 A61P 35/00
Abstract:
Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulations may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g. glioblastoma.
University of Southern California May 2009 - Sep 2015
Research Associate
University of Southern California May 2009 - Sep 2015
Post-Doctoral Researcher
Children's Hospital Los Angeles (Chla) Nov 2007 - Apr 2009
Post-Doctoral Research Fellow
Education:
Oregon State University 2001 - 2006
Doctorates, Doctor of Philosophy, Microbiology
Pukyong National University 1995 - 2000
Bachelors, Bachelor of Science, Biology, Aquaculture
Skills:
Immunoprecipitation Molecular Cloning Stem Cell Research In Vivo Experiment Primary Cell Isolation Qpcr Cell Culture Flow Cytometry Lentivirus Vector Prep/Transduction Western Blotting Gene Therapy Molecular Virology Lentivirus Vector Biochemical Assay
Unitedhealth Group
Associate Director, Actuarial Service
Unitedhealth Group Feb 2008 - May 2011
Actuarial Analyst
Aon Oct 2007 - Jan 2008
Actuarial Intern