- Duarte CA, US Qi Cui - Duarte CA, US Su Yang - San Diego CA, US
International Classification:
C12N 15/113 A01K 67/027 A61P 35/00 A61K 31/203
Abstract:
Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulation may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g., glioblastoma.
Targeting Glioblastoma Stem Cells Through The Tlx-Tet3 Axis
- Duarte CA, US Qi Cui - Duarte CA, US Su Yang - San Diego CA, US
International Classification:
C12N 15/113 A01K 67/027 A61P 35/00 A61K 31/203
Abstract:
Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulation may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g., glioblastoma.
Targeting Glioblastoma Stem Cells Through The Tlx-Tet3 Axis
- Duarte CA, US Qi Cui - Duarte CA, US Su Yang - San Diego CA, US
International Classification:
C12N 15/113 A61K 31/203 A61P 35/00
Abstract:
Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulations may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g. glioblastoma.