A method of identifying altered biomarker expression levels in a human serum specimen to diagnose asthma or non-small celled lung cancers in humans. The existence of asthma or non-small celled lung cancers in a patient can be determined by subjecting a blood sample from the patient to a simple blood test to determine the expression levels of certain specific biomarkers. The expression levels of the specific biomarkers are compared to ranges of expression levels for the same biomarkers which are indicative of individuals known to have asthma, non-small cell lung cancers, or neither. Comparing the expression levels will determine the existence or non-existence of asthma or non-small cell lung cancer.
Methods Of Identification, Assessment, Prevention And Therapy Of Lung Diseases And Kits Thereof
The invention provides biomarkers and combinations of biomarkers that are useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
Method Of Identifying Proteins In Human Serum Indicative Of Pathologies Of Human Lung Tissues
Robert T. Streeper - San Antonio TX, US Elzbieta Izbicka - San Antonio TX, US Sung H. Baek - Snohomish WA, US
Assignee:
Cancer Prevention and Cure, Ltd. - Michigan City IN
International Classification:
C40B 20/08 G01N 33/68 C12Q 1/37
US Classification:
506 6, 436 86, 435 24, 435 23
Abstract:
A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known to have non-small cell lung cancers and asthma, as diagnosed by a physician. Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identities of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
Methods Of Identification, Assessment, Prevention And Therapy Of Lung Diseases And Kits Thereof
Robert T. Streeper - San Antonio TX, US Elzbieta Izbicka - San Antonio TX, US Sung H. Baek - Snohomish WA, US
Assignee:
CANCER PREVENTION AND CURE., LTD - Michigan IN
International Classification:
C40B 30/04 C40B 40/10 G01N 27/62
US Classification:
506 9, 435 23, 506 18
Abstract:
The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subjects response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
Alex ALGARD - Seattle WA, US Gene HSU - Seattle WA, US Sung BAEK - Maple Valley WA, US Blake THOMSON - North Bethesda MD, US Debbie CARGILE - Seattle WA, US
Assignee:
WhitePages, Inc. - Seattle WA
International Classification:
G09G 5/377
US Classification:
345629
Abstract:
Neighbor mapping and communication systems and methods are provided herein.
Stratozone
Senior Manager
The Shelby Group Dec 1, 2015 - Dec 2016
Manager
Hubwoo Aug 2012 - Dec 2015
Manager Sourcing Technical Services
Hubwoo Jul 2011 - Aug 2012
Senior Consultant
Bank of America Apr 2010 - Jul 2011
Lead Ariba Programmer
Education:
University of Illinois at Chicago 1994 - 1999
Bachelors, Bachelor of Science, Computer Science
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Ariba Vendor Management Business Process Improvement E Procurement Spend Analysis Saas Business Process Requirements Analysis Sap Esourcing Strategic Sourcing Sdlc Business Analysis Procure To Pay Enterprise Software Software Project Management Software Implementation Business Intelligence Java