Sung M Chang

US Patent:

20040064053, Apr 1, 2004

Filed:

Sep 30, 2002

Appl. No.:

10/262610

Inventors:

Sung Chang - Austin TX, US
Yvette Mirabal - Houston TX, US
Michele Follen - Houston TX, US
Anais Malpica - Houston TX, US
Urs Utzinger - Tucson AZ, US
Gregg Staerkel - Pearland TX, US
Dennis Cox - Houston TX, US
E. Atkinson - Houston TX, US
Calum MacAulay - Vancouver, CA

International Classification:

A61B006/00

US Classification:

600/478000

Abstract:

Systems and methods are described for improved diagnostic fluorescence and reflectance. A method of detecting tissue abnormality in a tissue sample in vivo detects a set of reflectance spectra emitted from a tissue sample as a result of illumination with an excitation light from a fiber optic probe that has at least one collection fiber positioned at a source-detector separation, and determining if the tissue sample is normal or abnormal based on the resulting reflectance spectra. Another method of detecting tissue abnormality in a tissue sample in vivo includes illuminating the tissue sample in vivo with at least one electromagnetic radiation wavelength selected to cause the tissue sample to produce a set of fluorescence intensity spectra indicative of tissue abnormality, detecting the resulting fluorescence intensity spectra, and determining if the tissue sample is normal or abnormal based on the resulting fluorescence intensity spectra. Yet another method of detecting tissue abnormality in a tissue sample in vivo includes combining the two methods described above.