Sung Ho Hahm

US Patent:

20050227246, Oct 13, 2005

Filed:

Apr 8, 2005

Appl. No.:

10/907620

Inventors:

Sung Ho Hahm - Woodstock MD, US

International Classification:

C12Q001/68
C12N015/86
C12N015/74

US Classification:

435006000, 435455000, 435456000, 435471000

Abstract:

The present application discloses a method for making and selecting a transcription enhancing combined promoter cassette, which includes constructing a library of randomly combined transcription regulatory elements, which comprise double stranded DNA sequence elements that are recognized by transcription regulators; inserting the combined transcription regulatory elements upstream of a minimum promoter followed by a reporter gene in a vector; inserting the vector into a host cell; and then screening for the cells showing enhanced expression of the reporter gene, and identifying the combined promoter cassette in the cell.

US Patent:

20060019396, Jan 26, 2006

Filed:

Jun 7, 2005

Appl. No.:

11/160066

Inventors:

Sung Ho HAHM - Woodstock MD, US
Dug Keun LEE - Gaithersburg MD, US
Kwan Hee LEE - Gaithersburg MD, US
Youngsuk YI - Gaithersburg MD, US

Assignee:

TISSUEGENE, INC. - Gaithersburg MD

International Classification:

C12N 15/867

US Classification:

435456000

Abstract:

The present application discloses a MoMSV/MoMLV hybrid-based retroviral vector, wherein gag and pol genes are completely removed.

US Patent:

20060057610, Mar 16, 2006

Filed:

Oct 31, 2005

Appl. No.:

11/163794

Inventors:

Sung Ho HAHM - Woodstock MD, US

Assignee:

PROMOGEN, INC. - Gaithersburg MD

International Classification:

C40B 40/08

US Classification:

435006000

Abstract:

The present application discloses a method for making and selecting a transcription enhancing combined promoter cassette, which includes constructing a library of randomly combined transcription regulatory elements, which comprise double stranded DNA sequence elements that are recognized by transcription regulators; inserting the combined transcription regulatory elements upstream of a minimum promoter followed by a reporter gene in a vector; inserting the vector into a host cell; and then screening for the cells showing enhanced expression of the reporter gene, and identifying the combined promoter cassette in the cell.