Sung W Jo

US Patent:

20110237558, Sep 29, 2011

Filed:

Oct 2, 2009

Appl. No.:

12/998261

Inventors:

William Shifeng - Belle Mead NJ, US
Yiping Wang - Howell NJ, US
Jianzhen Pan - Monroe NJ, US
Sung Hi Jo - Philadelphia PA, US

International Classification:

A61K 31/59
A61P 17/06

US Classification:

514168, 514167

Abstract:

A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N-di(C-C)alkylamino substituted, (C-C)alkyl(C-C)carboxylic ester a (C-C)-alkyl(C-C)carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C-C)alkylamino substituted, (C-C)alkyl(C-C) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP).

US Patent:

20160067266, Mar 10, 2016

Filed:

Nov 13, 2015

Appl. No.:

14/941390

Inventors:

- San Diego CA, US
Yiping WANG - Howell NJ, US
Jianzhen PAN - Monroe NJ, US
Sung Hi JO - Philadelphia PA, US

Assignee:

NEXMED HOLDINGS, INC. - San Diego CA

International Classification:

A61K 31/59
A61K 31/355
A61K 31/573

Abstract:

A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N-di(C-C) alkylamino substituted, (C-C) alkyl (C-C) carboxylic ester a (C-C)-alkyl (C-C) carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C-C) alkylamino substituted, (C-C) alkyl (C-C) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP).