Sungjoon Joon Kim

US Patent:

7252944, Aug 7, 2007

Filed:

Jul 30, 2004

Appl. No.:

10/903334

Inventors:

Kavita Shah - Lafayette IN, US
Sungjoon Kim - San Diego CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

C12Q 1/68

US Classification:

435 6, 435 5, 435 691

Abstract:

This invention provides methods for identifying novel SHMT modulators. The methods comprise first screening test agents for modulators of p38 activity and then further screening the identified modulating agents for modulators of SHMT enzyme activity. The invention further provides methods and pharmaceutical compositions for modulating cellular proliferation and for treating tumors using the novel SHMT modulators.