Provided herein are small molecule CD mimetics effective to bind to HIV Env proteins. A CD mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD mimetics, for example, to elicit an immune response in a subject upon administration.
Hiv Polynucleotides And Polypeptides Derived From Botswana Mj4
The present disclosure relates to novel polynucleotides that encode HIV Env polypeptides. In particular, the disclosure relates to sequences derived from HIV strain Botswana MJ4 encoding Env polypeptides. Compositions comprising these polynucleotides and methods of using polynucleotides are also disclosed.
YING LIAN - VALLEJO CA, US JAN ZUR MEGEDE - SAN FRANCISCO CA, US INDRESH SRIVASTAVA - BENECIA CA, US SUSAN W. BARNETT - SAN FRANCISCO CA, US
Assignee:
NOVARTIS VACCINES AND DIAGNOSTICS, INC. - Emeryville CA
International Classification:
A61K 39/295
US Classification:
4242011
Abstract:
This invention is directed to pharmaceutical compositions comprising an HIV antigen and a mucosal adjuvant and methods for raising an immune response in a subject by administering these compositions. Preferably, the pharmaceutical compositions of the invention can be used to treat or prevent HIV infection.
Hiv Polynucleotides And Polypeptides Derived From Botswana Mj4
The present disclosure relates to novel polynucleotides that encode HIV Env polypeptides. In particular, the disclosure relates to sequences derived from HIV strain Botswana MJ4 encoding Env polypeptides. Compositions comprising these polynucleotides and methods of using these polynucleotides are also disclosed.
Indresh K. Srivastava - Benicia CA, US Victoria Sharma - Orinda CA, US Susan W. Barnett - San Francisco CA, US Jeffrey Ulmer - Danville CA, US
International Classification:
A61K 39/21 A61P 37/04
US Classification:
4242081
Abstract:
Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration.
Williamsville East School Williamsville NY 1980-1982, Williamsville East High School East Amherst NY 1980-1982, North Farmington High School Farmington MI 1982-1984
Community:
Michael Mclellen, Theodore Ted, Butch Crowe, Beverly Lough
It was mostly "all hands on deck," though 6ABC's Jim Gardner didn't wander in until midday Sunday, while eight-months-pregnant Susan Barnett worked almost 12 hours Saturday at CBS3 and showed up smiling again Sunday.