Susan Wynn Barnett

US Patent:

6602705, Aug 5, 2003

Filed:

Dec 30, 1999

Appl. No.:

09/475515

Inventors:

Susan W. Barnett - San Francisco CA
Jan zur Megede - San Francisco CA
Catherine Greer - Oakland CA
Mark Selby - San Francisco CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C12N 1500

US Classification:

4353201, 536 231, 536 2372, 4241841, 4241851, 4241871, 4241881, 4242071

Abstract:

The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.

US Patent:

6689879, Feb 10, 2004

Filed:

Dec 30, 1999

Appl. No.:

09/476242

Inventors:

Susan Barnett - San Francisco CA
Karin Hartog - Piedmont CA
Eric Martin - El Cerrito CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C07H 2104

US Classification:

536 2372, 536 231, 435 6, 4353201

Abstract:

Polynucleotide encoding modified HIV Env polypeptides are disclosed. The Env polypeptides are modified in the region of amino acids 420-436 so as to expose at least part of the CD4 binding region. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.

US Patent:

7211659, May 1, 2007

Filed:

Jul 5, 2002

Appl. No.:

10/190435

Inventors:

Jan zur Megede - San Francisco CA, US
Susan Barnett - San Francisco CA, US

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C07H 21/04
A61K 39/21
C12P 19/04
A61K 49/00
A61K 38/00
A61K 39/12
C12Q 1/68
C12Q 1/70

US Classification:

536 2372, 424 92, 4241921, 4241991, 4242081, 435 5, 435 6, 435 697, 435 701, 536 234

Abstract:

The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

US Patent:

7282364, Oct 16, 2007

Filed:

Oct 29, 2004

Appl. No.:

10/976619

Inventors:

Jan Zur Megede - San Francisco CA, US
Susan Barnett - San Francisco CA, US
Ying Lian - Albany CA, US

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

C12N 15/00

US Classification:

4353201, 435 691, 536 234, 536 2372

Abstract:

The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

US Patent:

7618642, Nov 17, 2009

Filed:

Jul 5, 2001

Appl. No.:

09/899575

Inventors:

Jan zur Megede - San Francisco CA, US
Susan Barnett - San Francisco CA, US
Ying Lian - Vallejo CA, US
Susan Engelbrecht - Tygerberg, ZA
Estrelita Janse van Rensburg - Tygerberg, ZA

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

A61K 39/21
C12P 21/06
C07H 21/04

US Classification:

4242081, 4241881, 435 691, 536 2372

Abstract:

The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of HIV Type C proteins are also described.

US Patent:

7622125, Nov 24, 2009

Filed:

May 5, 2005

Appl. No.:

11/124602

Inventors:

Jan zur Megede - San Francisco CA, US
Susan W. Barnett - San Francisco CA, US

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

A61K 39/12
A61K 39/21
C07H 21/02
C07H 21/04

US Classification:

4242041, 4242051, 4242071, 4242081, 536 231, 536 234, 536 237, 536 2372

Abstract:

The present disclosure relates to vectors comprising polynucleotide sequences that encode HIV polypeptides. In particular, the disclosure relates polycistronic vector constructs comprising sequences that encode HIV polypeptides as a single polyprotein. Compositions comprising these vectors and sequences along with methods of using these vectors and sequences are also disclosed.

US Patent:

7662916, Feb 16, 2010

Filed:

Jul 25, 2003

Appl. No.:

10/452018

Inventors:

Susan Barnett - San Francisco CA, US
Karin Hartog - Piedmont CA, US
Eric Martin - El Cerrito CA, US

Assignee:

Novartis Vaccines & Diagnostics, Inc - Emeryville CA

International Classification:

C07K 14/00
A61K 39/00

US Classification:

530350, 4241841

Abstract:

Polynucleotide encoding modified HIV Env polypeptides are disclosed. The Env polypeptides are modified so as to expose at least part of the CD4 binding region. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.

US Patent:

7718401, May 18, 2010

Filed:

Feb 6, 2008

Appl. No.:

12/026619

Inventors:

Susan W. Barnett - San Francisco CA, US
Jan zur Megede - San Francisco CA, US
Indresh Srivastava - Concord CA, US
Ying Lian - Vallejo CA, US
Karin Hartog - Piedmont CA, US
Hong Liu - Castro Valley CA, US
Catherine Greer - Emeryville CA, US
Mark Selby - San Francisco CA, US
Christopher Walker - Blacklick OH, US

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

C12N 15/00
A61K 39/21

US Classification:

435 691, 4353201, 4242081

Abstract:

The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.