Susan M Minton

US Patent:

20070031871, Feb 8, 2007

Filed:

Jul 20, 2006

Appl. No.:

11/490316

Inventors:

Richard Jove - Glendora CA, US
Susan Minton - Tampa FL, US
Daniel Sullivan - Lutz FL, US
Eric Haura - Tampa FL, US
Gerold Bepler - Tierra Verde FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

C12Q 1/68
G01N 33/574

US Classification:

435006000, 435007230

Abstract:

Methods are provided for predicting responsiveness of cancer cells to chemotherapy by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Also provided are methods of selecting a chemotherapeutic treatment for a subject diagnosed with cancer by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing the level in the cancer cell to the respective level in a control. Kits for performing the methods are also provided. Methods for modulating Survivin-dependent apoptosis in a cancer cell are also disclosed.