Bradford C. Van Wagenen - Salt Lake City UT, US Scott T. Moe - Ann Arbor MI, US Daryl L. Smith - Fishers IN, US Susan M. Sheehan - Dexter MI, US Irina Shcherbakova - Salt Lake City UT, US Ruth Walton - Bountiful UT, US Richard Trovato - Salt Lake City UT, US Robert Barmore - Salt Lake City UT, US Eric G. Delmar - Salt Lake City UT, US Thomas M. Stormann - Salt Lake City UT, US
Assignee:
NPS Pharmaceuticals, Inc. - Salt Lake City UT
International Classification:
A61K 31/47 C07D 215/14
US Classification:
514311, 546169, 546 90, 514291
Abstract:
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
Heteropolycyclic Compounds And Their Use As Metabotropic Glutamate Receptor Antagonists
Bradford Van Wagenen - Salt Lake City UT, US Thomas M. Stormann - Salt Lake City UT, US Scott T Moe - Marlborough UT, US Susan M Sheehan - Dexter MI, US Donald McLeod - Salt Lake City UT, US Daryl L Smith - Fishers IN, US Methvin Isaac - Toronto, CA Abdelmalik Slassi - Toronto, CA Ian Egle - Toronto, CA Louise Edwards - Toronto, CA Tomislav Stefanac - Toronto, CA Tao Xin - Toronto, CA Jalaj Arora - Toronto, CA William Michne - Wilmington DE, US
Assignee:
NPS Pharmaceuticals, Inc. - Salt Lake City UT Astrazeneca AB - Sodertalje
International Classification:
A61K 31/44 C07D 401/02
US Classification:
514340, 5462691
Abstract:
The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
Novel Norepinephrine Reuptake Inhibitors For The Treatment Of Central Nervous System Disorders
Bradley Caprathe - Livonia MI, US Shelly Glase - Ann Arbor MI, US Zissis Konstantinou - Scarborough, CA Robert Schelkun - Milan MI, US Susan Sheehan - Dexter MI, US Anthony Thomas - Ann Arbor MI, US
International Classification:
A61K031/517 C07D043/02
US Classification:
514252170, 514266220, 544284000
Abstract:
This invention relates to compounds of the formula 1 wherein R, R, and Rand Rare defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
Heteropolycyclic Compounds And Their Use As Metabotropic Glutamate Receptor Antagonists
Bradford Wagenen - Salt Lake City UT, US Thomas Stormann - Salt Lake City UT, US Scott Moe - Marlborough MA, US Susan Sheehan - Dexter MI, US Donald McLeod - Salt Lake City UT, US Daryl Smith - Fishers IN, US Methvin Isaac - Toronto, CA Abdelmalik Slassi - Toronto, CA Ian Egle - Toronto, CA Louise Edwards - Totonto, CA Tomislav Stefanac - Toronto, CA Tao Xin - Toronto, CA Jalaj Arora - Toronto, CA William Michne - Wilmington DE, US
International Classification:
C07D 413/04 A61K 31/4439
US Classification:
514342000, 546269400
Abstract:
The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
Michelle Bruendl - Ann Arbor MI, US Keri Greene - Canton MI, US Rex Jennings - Gregory MI, US Scott Lazerwith - Ann Arbor MI, US Joe Nahra - Canton MI, US Patrick O'Brien - Stockbridge MI, US Kimberly Para - Ann Arbor MI, US Susan Sheehan - Dexter MI, US
The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Rand Rhave any of the values defined therefor in the specification; pharmaceutical compositions; methods of treating conditions, diseases, and disorders; and therapeutic combinations.
Metabotropic Glutamate Receptor Antagonists And Their Use For Treating Central Nervous System Diseases
Bradford C. Van Wagenen - Salt Lake City UT Scott T. Moe - Salt Lake City UT Daryl L. Smith - Salt Lake City UT Susan M. Sheehan - Dexter MI Irina Shcherbakova - Salt Lake City UT Richard Travato - Salt Lake City UT Ruth Walton - Ogden UT Robert Barmore - Salt Lake City UT Eric G. Delmar - Salt Lake City UT Thomas M. Stormann - Salt Lake City UT
Assignee:
NPS Pharmaceuticals, Inc. - Salt Lake City UT
International Classification:
A61K 31498
US Classification:
514249, 544355, 544354, 544353
Abstract:
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
- Parsippany NJ, US Matthew W. Bedore - Portage MI, US Paul D. Johnson - Kalamazoo MI, US Tomasz Respondek - Kalamazoo MI, US Susan M.K. Sheehan - Galesburg MI, US Graham M. Kyne - Portage MI, US Richard A. Ewin - Kalamazoo MI, US Rajendran Vairagoundar - Kalamazoo MI, US Michael P. Curtis - Portage MI, US
The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereofwherein each of R, R, R, R, L, and Lare as defined herein. The present invention also contemplates compositions, methods of treatment, and uses as a medicament to treat an animal for an endoparasitic infection with a Formula (1) compound.
- Parsippany NJ, US Susan M. Sheehan - Galesburg MI, US Graham M. Kyne - Portage MI, US Matthew W. Bedore - Portage MI, US Richard A. Ewin - Kalamazoo MI, US Paul D. Johnson - Kalamazoo MI, US Tom L. McTier - Kalamazoo MI, US Christopher S. Knauer - Kalamazoo MI, US Rajendran Vairagoundar - Kalamazoo MI, US
The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereofwherein each of R, R, R, R, L, and L, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.
Huntsman was not available for comment, but Susan Sheehan, President and Chief Operating Officer at the Huntsman Cancer Foundation, says they are exploring all options when it comes to the handling of Beckerles termination.
Date: Apr 19, 2017
Category: Health
Source: Google
Microsoft Board Said to Work on Hiring New CEO This Year
Jennifer Hakes, a spokeswoman for EBay, said Donahoe wasnt available for comment. Susan Sheehan, a spokeswoman for Nokia, declined to comment, as did David Oro, a spokesman for Pivotal. Gordon Goldstein, a spokesman for Silver Lake, didnt immediately return a call for comment.
Susan Sheehan, a Nokia spokeswoman, said in an interview that the company was glad that AT&T had committed to marketing the Lumia 920 and training retail employees on selling the phone. She hinted that there would be partnerships soon with other carriers but declined to go into detail about what
Date: Oct 05, 2012
Category: Sci/Tech
Source: Google
Nokia to Conduct Ethics Review Into Misleading Ad Video
The ethics and compliance officer is working on anindependent report to understand what happened, Susan Sheehan, a Nokia (NOK1V) spokeswoman, said today in an interview. Nokiasaid last week it was sorry for not making clear that apromotional video and still photos within that clip werentcaptu
More information about the ethics investigation unfolded today. Speaking to Bloomberg, Nokia representative Susan Sheehan said the company's ethics and compliance officer is looking into the matter. "What we understand to date is that it was nobody's intention to mislead, but there was poor judgment
Date: Sep 10, 2012
Category: Sci/Tech
Source: Google
Nokia Doubling Sends Stock to Nine-Year High to Forecasts
Eighteen months ago we outlined a deliberate strategy todeliver people great mobile products, said Susan Sheehan, aNokia spokeswoman in Espoo. Every day, we are focused onmaking process against that plan. She declined to talk aboutthe companys shares.
une, Nokia appointed Juha Putkiranta as executive vice president of Operations; Timo Toikkanen as executive vice president of Mobile Phones; Chris Weber as executive vice president of Sales and Marketing; Tuula Rytila as senior vice president of Marketing and chief marketing officer; and Susan Sheehan
Date: Jul 19, 2012
Source: Google
Nokia announces executive changes; renews Leadership Team
announced that it has appointed Juha Putkiranta as executive vice president of operations; Timo Toikkanen as executive vice president of Mobile Phones, Chris Weber as executive vice president of sales and marketing; Tuula Rytila as senior vice president and chief marketing officer; and Susan Sheehan
Date: Jun 14, 2012
Category: Sci/Tech
Source: Google
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