Susan J Spencer

US Patent:

7547768, Jun 16, 2009

Filed:

Nov 20, 2007

Appl. No.:

11/943454

Inventors:

Patrick Dowd - San Francisco CA, US
Gretchen Frantz - San Francisco CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Susan D. Spencer - Tiburon CA, US
Thomas D. Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 16/00
C12P 21/08
C12P 21/04
A61K 39/395
C07H 21/04

US Classification:

5303881, 4241331, 4241411, 4241551, 4241811, 435 696, 435 7021, 5303873, 5303888, 5303917

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

7767403, Aug 3, 2010

Filed:

Sep 29, 2004

Appl. No.:

10/953264

Inventors:

Gretchen Frantz - San Francisco CA, US
Paul Polakis - Burlingame CA, US
Susan D. Spencer - Tiburon CA, US
Thomas D. Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

G01N 33/53

US Classification:

435 71, 435 723, 5303871, 5303873, 5303881

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

7939268, May 10, 2011

Filed:

May 15, 2007

Appl. No.:

11/804045

Inventors:

Gretchen Frantz - San Francisco CA, US
Kenneth J. Hillan - San Francisco CA, US
Heidi Phillips - San Carlos CA, US
Paul Polakis - Burlingame CA, US
Susan D. Spencer - Tiburon CA, US
P. Mickey Williams - Half Moon Bay CA, US
Thomas D. Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

7951546, May 31, 2011

Filed:

May 29, 2008

Appl. No.:

12/156180

Inventors:

Gretchen Frantz - San Francisco CA, US
Kenneth J. Hillan - San Francisco CA, US
Heidi Phillips - San Carlos CA, US
Paul Polakis - Burlingame CA, US
Susan D. Spencer - Tiburon CA, US
P. Mickey Williams - Half Moon Bay CA, US
Thomas D. Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genetech, Inc. - South San Francisco CA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

8142784, Mar 27, 2012

Filed:

Dec 2, 2008

Appl. No.:

12/326721

Inventors:

Frederic S. Jacobson - Berkeley CA, US
Paul Polakis - Burlingame CA, US
Ralph H. Schwall - Pacifica CA, US
Mark X. Sliwkowski - San Carlos CA, US
Susan D. Spencer - Tiburon CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 39/395

US Classification:

4241811, 4241781, 5303911, 5303915, 5303917

Abstract:

The present invention relates to antibody-drug conjugate compounds of Formula I:Ab-(L-D)  I.

US Patent:

8398982, Mar 19, 2013

Filed:

Apr 13, 2009

Appl. No.:

12/422424

Inventors:

Patrick Dowd - San Francisco CA, US
Gretchen Frantz - San Francisco CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Susan D. Spencer - Tiburon CA, US
Thomas D. Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 39/00

US Classification:

4241781, 4241821, 4241831

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. TAT113 polypeptides comprising the amino acid sequence of SEQ ID NO: 2 are disclosed. Antibodies that bind TAT113 polypeptides, including monoclonal, chimeric, humanized, single chain, and other antibodies, and fragments thereof, are disclosed. Methods of identifying antibodies that bind epitopes bound by such antibodies, including the antibodies produced by hybridoma cell lines disclosed in the application, are provided, wherein the ability of one antibody to block the binding of another antibody to a TAT113 polypeptide indicates that one antibody binds to an epitope bound by the other antibody. Methods of diagnosing the presence of a tumor in a mammal using such antibodies are disclosed, wherein detection of the formation of a complex between an antibody and a protein in a test sample is indicative of the presence of a tumor in said mammal. Methods of inhibiting the growth of a cancer cell that expresses a protein comprising the amino acid sequence of SEQ ID NO: 2, are disclosed, where the binding of the antibody to the protein inhibits the growth of the cell.

US Patent:

20030148408, Aug 7, 2003

Filed:

Sep 11, 2002

Appl. No.:

10/241220

Inventors:

Gretchen Frantz - San Francisco CA, US
Kenneth Hillan - San Francisco CA, US
Heidi Phillips - San Carlos CA, US
Paul Polakis - Burlingame CA, US
Susan Spencer - Tiburon CA, US
P. Williams - Half Moon Bay CA, US
Thomas Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

GENENTECH, INC.

International Classification:

G01N033/574
C07K016/30

US Classification:

435/007230, 530/388800

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

US Patent:

20030228305, Dec 11, 2003

Filed:

Dec 30, 2002

Appl. No.:

10/331496

Inventors:

Gretchen Frantz - San Francisco CA, US
Kenneth Hillan - San Francisco CA, US
Heidi Phillips - Palo Alto CA, US
Paul Polakis - Burlingame CA, US
Victoria Smith - Burlingame CA, US
Susan Spencer - Tiburon CA, US
P. Williams - Half Moon Bay CA, US
Thomas Wu - San Francisco CA, US
Zemin Zhang - Foster City CA, US

Assignee:

GENENTECH, INC.

International Classification:

A61K039/395
C07K016/44

US Classification:

424/141100, 530/388150

Abstract:

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.