Susan Jean Stuart

US Patent:

6444430, Sep 3, 2002

Filed:

Mar 19, 2001

Appl. No.:

09/812484

Inventors:

Susan G. Stuart - Montara CA
Janice Au-Young - Brisbane CA
Jennifer L. Hillman - Mountain View CA
Purvi Shah - San Jose CA
Henry Yue - Sunnyvale CA

Assignee:

Incyte Genomics, Inc. - Palo Alto CA

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 536 221, 536 231, 536 2431, 536 2432

Abstract:

The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.

US Patent:

6534275, Mar 18, 2003

Filed:

Jan 14, 2000

Appl. No.:

09/483665

Inventors:

Susan G. Stuart - Montara CA
Phillip R. Hawkins - Mountain View CA
Jeffrey J. Seilhamer - Los Altos Hills CA
Lynn E. Murry - Portola Valley CA

Assignee:

Incyte Genomics, Corp. - Palo Alto CA

International Classification:

G01N 3353

US Classification:

435 71, 530700, 530350

Abstract:

The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.

US Patent:

20020155527, Oct 24, 2002

Filed:

Jan 26, 2001

Appl. No.:

09/769508

Inventors:

Susan Stuart - Montara CA, US
John Monahan - Orinda CA, US
Beatrice Langton - Walnut Creek CA, US
Miriam Hancock - Oakland CA, US
Lorrine Chao - San Francisco CA, US
Peter Bluford - Richmond CA, US

Assignee:

Triton BioSciences, Inc.

International Classification:

C12P021/02
C12N005/06
C07K014/705
G01N033/574
C07H021/04

US Classification:

435/069100, 435/007230, 435/325000, 435/320100, 530/350000, 536/023500

Abstract:

Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quantitate the level of gp75 in the biological fluids of mammals carrying a tumor burden. Further disclosed are recombinant, synthetically and otherwise biologically produced novel proteins and polypeptides which are encoded by the external domain DNA sequence of the c-erbB-2 oncogene (the gp75 gene) or fragments thereof. Such gp75 proteins and polypeptides are useful as vaccines, therapeutically in the treatment of cancer either alone or in combination with chemotherapeutic agents. Also disclosed are antibodies to such gp75 proteins and polypeptides which are useful diagnostically and therapeutically. Still further disclosed are test kits embodying the assays of this invention.

US Patent:

20030119009, Jun 26, 2003

Filed:

Feb 25, 2002

Appl. No.:

10/084817

Inventors:

Susan Stuart - Montara CA, US
Jed Nuchtern - Houston TX, US
Sharon Plon - Houston TX, US
Jason Shohet - Pearland TX, US

International Classification:

C12Q001/68
C07H021/04
C12P019/34
C12N009/00
C12P021/02
C12N005/08

US Classification:

435/006000, 435/069100, 435/091200, 435/183000, 435/320100, 435/368000, 536/023200

Abstract:

The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed by MYCN activation and which may be used in their entirety or in part to diagnose, to stage, to treat, or to monitor the treatment of a subject with neuroblastoma.

US Patent:

20030124543, Jul 3, 2003

Filed:

Feb 20, 2002

Appl. No.:

10/079111

Inventors:

Susan Stuart - Montara CA, US
David Streeter - Boulder Creek CA, US

International Classification:

C12Q001/68
G01N033/574
C07H021/04
C12P021/02
C12N005/06
C12P019/34
C12N009/00

US Classification:

435/006000, 435/091200, 435/069100, 435/320100, 435/325000, 435/007230, 435/183000, 530/388260, 536/023200

Abstract:

The invention provides a cDNA which encodes a protein differentially expressed in breast cancer. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly a breast cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

US Patent:

20030138835, Jul 24, 2003

Filed:

Jan 21, 2003

Appl. No.:

10/349436

Inventors:

Susan Stuart - Montara CA, US
Henry Yue - Sunnyvale CA, US
Mariah Baughn - San Leandro CA, US
David Streeter - Boulder Creek CA, US

Assignee:

Incyte Genomics, Inc. - Palo Alto CA

International Classification:

C12Q001/68
G01N033/574
C07H021/04
C12P021/02
C12N005/06
C07K014/72

US Classification:

435/006000, 435/007230, 435/069100, 435/320100, 435/325000, 530/350000, 536/023500, 536/024300

Abstract:

The invention provides a mammalian cDNA which encodes a mammalian MTSP. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly breast cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

US Patent:

20030167480, Sep 4, 2003

Filed:

Jun 13, 2002

Appl. No.:

10/172069

Inventors:

Susan Stuart - Montara CA, US
Janice Au-Young - Brisbane CA, US
Jennifer Hillman - Fremont CA, US
Purvi Shah - San Jose CA, US
Henry Yue - Sunnyvale CA, US

Assignee:

Incyte Genomics, Inc. - Palo Alto CA

International Classification:

A01K067/00
C12Q001/68
C12P021/04
C12N009/64
C12P021/02
C12N005/06

US Classification:

800/008000, 435/226000, 435/069100, 435/325000, 435/320100, 435/070210, 530/388260, 435/006000, 435/007230

Abstract:

The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.

US Patent:

20030180931, Sep 25, 2003

Filed:

Jan 29, 2003

Appl. No.:

10/357028

Inventors:

Susan Stuart - Montara CA, US
Phillip Hawkins - Mountain View CA, US
Jeffrey Seilhamer - Los Altos Hills CA, US
Lynn Murry - Fayetteville AR, US

Assignee:

Incyte Genomics, Inc. - Palo Alto CA

International Classification:

C12Q001/68
C07H021/04
C12N009/24
C12P021/02
C12N005/06

US Classification:

435/200000, 435/006000, 435/069100, 435/320100, 435/325000, 536/023200, 530/388260

Abstract:

The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.