Susana A Maldonado

US Patent:

7838481, Nov 23, 2010

Filed:

Apr 7, 2006

Appl. No.:

11/399813

Inventors:

Mirta I. Riesgo - Miami FL, US
Carlos S. Rubio - Hialeah FL, US
Susana M. Maldonado - Miami FL, US

Assignee:

Beckman Coulter, Inc. - Fullerton CA

International Classification:

C11D 3/20

US Classification:

510161, 510179, 510382, 510386

Abstract:

A formaldehyde-free cleaner composition and method of use for maintaining a blood analyzer are disclosed. The cleaner composition includes surfactants, a proteolytic enzyme, non-formaldehyde releasing antimicrobials, alkaline metal salts, and a buffer. The cleaner composition has a pH in a range from about 7 to about 12 and a formaldehyde concentration equal or less than 1 ppm.

US Patent:

20060263889, Nov 23, 2006

Filed:

May 4, 2005

Appl. No.:

11/125395

Inventors:

Russell Lang - Pembroke Pines FL, US
Dennisse Parra-Diaz - Miami FL, US
Luisa Oramas - Weston FL, US
Barbara Murza - Miami FL, US
Susana Maldonado - Miami FL, US

Assignee:

Beckman Coulter, Inc. - Fullerton CA

International Classification:

G01N 33/72

US Classification:

436066000

Abstract:

A cyanide-free lytic reagent composition and method of use for measuring the total hemoglobin concentration and white blood cells in a blood sample are disclosed. The lytic reagent composition includes a quaternary ammonium surfactant to lyse red blood cells and release hemoglobin and a ligand to form a stable chromogen with the hemoglobin. The lytic reagent composition has a pH in a range of 3 to 10. The lytic reagent composition can also include a second quaternary ammonium surfactant. The ligand can be malic acid, malonic acid, ethylene diamine, N,N-diethylethylene diamine, N,N′-diethylethylene diamine, diethylene triamine, tetraethylene pentamine, 1,6-hexanediamine, 1,3-pentanediamine, 2-methylpentamethylenediamine, 1,2-diaminocyclohexane, 4-aminoacetophenone, bis-hexamethylenetriamine, pyridazine, or 3,6-dihyroxypyridazine.