Sushmita Roy

US Patent:

20050116159, Jun 2, 2005

Filed:

Dec 27, 2004

Appl. No.:

11/023234

Inventors:

Christopher Becker - Palo Alto CA, US
Curtis Hastings - Bethesda MD, US
Scott Norton - Durham NC, US
Sushmita Roy - Santa Clara CA, US
Weixun Wang - Mountain View CA, US
Haihong Zhou - Mountain View CA, US
Thomas Shaler - Fremont CA, US
Praveen Kumar - Santa Clara CA, US
Markus Anderle - Campbell CA, US
Hua Lin - Sunnyvale CA, US

Assignee:

SurroMed, Inc. - Menlo Park CA

International Classification:

H01J049/00

US Classification:

250281000

Abstract:

Relative quantitative information about components of chemical or biological samples can be obtained from mass spectra by normalizing the spectra to yield peak intensity values that accurately reflect concentrations of the responsible species. A normalization factor is computed from peak intensities of those inherent components whose concentration remains constant across a series of samples. Relative concentrations of a component occurring in different samples can be estimated from the normalized peak intensities. Unlike conventional methods, internal standards or additional reagents are not required. The methods are particularly useful for differential phenotyping in proteomics and metabolomics research, in which molecules varying in concentration across samples are identified. These identified species may serve as biological markers for disease or response to therapy.

US Patent:

20050266467, Dec 1, 2005

Filed:

May 19, 2005

Appl. No.:

11/134046

Inventors:

Sushmita Roy - Sunnyvale CA, US

Assignee:

PPD Biomarker Discovery Sciences, LLC - Wilmington NC

International Classification:

C12Q001/68
G01N033/53
G01N033/567

US Classification:

435006000, 435007200

Abstract:

Disclosed are biomarkers, the expression of which is differentially regulated in subjects with multiple sclerosis (MS) as compared to subjects that do not have MS. Also described are methods of identification of such biomarkers, and methods of using such biomarkers as targets for the development and identification of therapeutic compounds and strategies for the treatment of MS, as well as methods and kits for the diagnosis of MS.

US Patent:

20090042201, Feb 12, 2009

Filed:

Jun 27, 2008

Appl. No.:

12/163793

Inventors:

Sushmita Mimi Roy - Sunnyvale CA, US

Assignee:

PPD BIOMARKER DISCOVERY SCIENCES LLC - Wilmington NC

International Classification:

C12Q 1/68
C12Q 1/00
C12Q 1/32
G01N 33/53
C07K 16/18

US Classification:

435 6, 435 4, 435 26, 435 78, 5303871, 5303879, 5303913

Abstract:

Disclosed are biomarkers, the expression of which is differentially regulated in subjects with multiple sclerosis (MS) as compared to subjects that do not have MS. Also described are methods of identification of such biomarkers, and methods of using such biomarkers as targets for the development and identification of therapeutic compounds and strategies for the treatment of MS, as well as methods and kits for the diagnosis of MS.

US Patent:

20110262946, Oct 27, 2011

Filed:

Apr 14, 2011

Appl. No.:

13/087075

Inventors:

Sushmita Mimi Roy - Sunnyvale CA, US
Sunil Bajad - Fremont CA, US
Evan Green - Mountain View CA, US
Henry Heinsohn - Alameda CA, US

Assignee:

Sutro Biopharma, Inc. - South San Francisco CA

International Classification:

C12Q 1/37
C12P 21/00

US Classification:

435 23, 435 681

Abstract:

The present invention provides a method for monitoring of profile changes of components in a dynamic system such as a cell-free in vitro protein synthesis system by using liquid chromatography (LC) combined with mass spectrometry (MS). In an additional aspect, this invention provides a method for enhancing the yield and/or reproducibility in a cell-free protein synthesis system by modulating the level and/or activity of a protein component that has regulatory effects on the system.

US Patent:

20160022174, Jan 28, 2016

Filed:

Jan 19, 2015

Appl. No.:

14/599971

Inventors:

Sandeep Patil - Menlo Park CA, US
Sushmita Roy - Sunnyvale CA, US

International Classification:

A61B 5/11
A61B 5/00

Abstract:

A monitoring device mounted to a user can be used to estimate a position or orientation of a body portion of the user, such as a joint or jointed portion of the user. Radiation can be emitted toward the body portion and a reflection of this radiation can be received. The reflected radiation can then be used to estimate a position of the body portion of the user.