Andrew Luster - Wellesley MA, US Sylvie Abi-Younes - Westwood MA, US
International Classification:
A61K039/395
US Classification:
424/146100, 424/130100
Abstract:
Disclosed herein is a method of identifying a compound which affects the interaction between SDF-1 and platelets, comprising the steps of contacting SDF-1 with platelets in the presence of a test compound in a test sample; (b) contacting SDF-1 with platelets in the absence of a test compound in a control sample; (c) measuring the SDF-1 effect in said test and said control samples; and (d) identifying compounds which increase or decrease said SDF-1 effect in the test sample compared to the control sample. method of treating a patient with a vascular disease by administering an inhibitor of the interaction between stromal cell derived factor-1 (SDF-1) and platelets, in an amount effective to reduce the symptoms of said disease. Also disclosed is a method of stimulating the interaction between SDF-1 and platelets, as well as methods to identify compounds that modulate the above interaction.
Medicine Doctors
Dr. Sylvie A Abi-Younes, Attleboro MA - MD (Doctor of Medicine)
Allergy and Asthma Specialty Physical 550 N Main St Suite B, Attleboro, MA 02703
Allergy and Asthma Specialty Physical 825 Washington St Suite 380, Norwood, MA 02062
Norwood Hospital 800 Washington Street, Norwood, MA 02062
Sturdy Memorial Hospital 211 Parks Street, Attleboro, MA 02703
Education:
Medical School University Of St Joseph Faculty Of Med Graduated: 1989 Medical School Cleveland Clinic Graduated: 1989 Medical School Cleveland Clinic Fndn Graduated: 1989 Medical School Mass Gen Hospital Graduated: 1989 Medical School Yale New Haven Hospital Graduated: 1989
Allergy & Asthma Specialty Physicians 825 Washington St STE 380, Norwood, MA 02062 (781)7699045 (phone), (781)7690420 (fax)
Allergy & Asthma Specialty Physicians 550 N Main St STE B, Attleboro, MA 02703 (781)7699045 (phone), (781)7690420 (fax)
Education:
Medical School St Joseph's Univ, Fac of Med, Beirut, Lebanon Graduated: 1989
Procedures:
Pulmonary Function Tests
Conditions:
Allergic Rhinitis Bronchial Asthma
Languages:
English French Spanish
Description:
Dr. Abi-Younes graduated from the St Joseph's Univ, Fac of Med, Beirut, Lebanon in 1989. She works in Attleboro, MA and 1 other location and specializes in Allergy & Immunology. Dr. Abi-Younes is affiliated with Norwood Hospital and Sturdy Memorial Hospital.
Allergy & Asthma Specialty Physicians 9 Summer St UNIT 205, Franklin, MA 02038 (508)5202255 (phone), (781)7690420 (fax)
Languages:
English
Description:
Dr. Abi-Younes works in Franklin, MA and specializes in Allergy & Immunology. Dr. Abi-Younes is affiliated with Massachusetts General Hospital, Milford Regional Medical Center, Morton Hospital and Steward Carney Hospital.