Terrence Dahl - Sunnyvale CA, US Mark Menning - San Francisco CA, US Reza Oliyai - San Carlos CA, US Taiyin Yang - Saratoga CA, US
International Classification:
A61K 31/675 A61K 9/20
US Classification:
424464000, 514081000
Abstract:
This invention is directed to a composition comprising dry granulated tenofovir DF and emtricitabine, and a method for making same. Dry granulation was unexpectedly found to be important in preparing a tenofovir DF containing composition suitable for inclusion in a combination dosage form containing emtricitabine, efavirenz and tenofovir DF.
Terrence Dahl - Sunnyvale CA, US Munir Hussain - Belle Mead NJ, US Robert Lipper - Pennington NJ, US Robert Jerzewski - Belle Mead NJ, US Mark Menning - San Francisco CA, US Reza Oliyai - San Carlos CA, US Taiyin Yang - Saratoga CA, US
International Classification:
A61K 31/551 A61K 31/522 A61K 31/513
US Classification:
514221000, 514263320, 514269000
Abstract:
In accordance with this invention a novel pharmaceutical product containing efavirenz, emtricitabine and tenofovir DF are provided as a multicomponent unitary oral dosage form, component 1 comprising tenofovir DF (and, optionally, emtricitabine) and component 2 comprising efavirenz, wherein components 1 and 2 are in a stabilizing configuration. In preferred embodiments component 1 is made by dry granulation.