Tammy Lynn Lawrence

US Patent:

6686163, Feb 3, 2004

Filed:

Dec 20, 2001

Appl. No.:

10/022819

Inventors:

Antonette C. P. Allen - Severn MD
Tracy S. Angelly - Gaithersburg MD
Tammy Lawrence - Laurel MD
Sheri J. Olson - Falls Church VA
Mark B. Rabin - Rockville MD

Assignee:

Gene Logic Inc. - Gaithersburg MD

International Classification:

C12Q 168

US Classification:

435 6, 4353201, 435 691, 435325, 536 231, 536 243, 536 2432, 536 235, 530350

Abstract:

The invention is directed to isolated coding sequences and to the protein sequences they code for. The coding sequence for BRCA1(omi4) gene is provided together with the protein sequence it codes for. The BRCA1(omi4) sequence is used for identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because the patient has an inherited causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with the isolated BRCA1(omi4) coding sequence and protein replacement therapy with the BRCA1(omi4) protein.

US Patent:

60836989, Jul 4, 2000

Filed:

Dec 11, 1997

Appl. No.:

8/988706

Inventors:

Sheri Jon Olson - Falls Church VA
Tracy Staton Angelly - Gaithersburg MD
Tammy Lawrence - Laurel MD
Jennifer Lee Lescallett - Great Falls VA
Patricia Davis Murphy - Slingerlands NY
Antonette Preisinger Allen - Severn MD
Denise Bernadette Thurber - Silver Spring MD
Marga Belle White - Frederick MD
Bin Zeng - Indianapolis IN
Lisa K. Sadzewicz - Laurel MD

Assignee:

Oncormed, Inc. - Gaithersburg MD

International Classification:

C12Q 168
C12Q 1934
C07H 2104
C12N 1585

US Classification:

435 6

Abstract:

New mutations have been found in the BRCA1 gene. The mutations are located at nucleotide numbers 421-2, 815, 903, 926, 1506, 2034, 2428, 3888, 3904, 4164, 4643, 5053, 5150, 5210, or 5396+40 of the gene sequence of BRCA1. A process for identifying a sequence variation in a BRCA1 polynucleotide sequence is disclosed. The identification process includes allele specific sequence-based assays of known sequence variations. The methods can be used for efficient, and accurate detection of a mutation in a test BRCA1 gene sample.

US Patent:

60513799, Apr 18, 2000

Filed:

Dec 2, 1997

Appl. No.:

8/984034

Inventors:

Jennifer Lee Lescallett - Great Falls VA
Tammy Lawrence - Laurel MD
Antonette Preisinger Allen - Severn MD
Sheri Jon Olson - Falls Church VA
Denise Bernadette Thurber - Silver Spring MD
Marga Belle White - Frederick MD

Assignee:

Oncormed, Inc. - Gaithersburg MD

International Classification:

C12Q 168
C07H 2104

US Classification:

435 6

Abstract:

New mutations have been found in the BRCA2 gene. The mutations are located at nucleotide numbers 2192, 3772, 5193, 5374, 6495 or 6909 of the published nucleotide sequence of BRCA2 gene. A process for identifying a sequence variation in a BRCA2 polynucleotide sequence is disclosed. The identification process includes allele specific sequence-based assays of known sequence variations. The methods can be used for efficient, and accurate detection of a mutation in a test BRCA2 gene sample.