An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.
Method And Apparatus For Preparing Cytological Specimens
Roy A. Ostgaard - Bolton MA Lewis A. Capriccio - Westford MA Theodore S. Geiselman - Bolton MA Robert E. Jennings - Andover MA Bruce Levkoff - Sharon MA Edward OConnell - Medford MA Douglas A. Tenney - North Reading MA Hugh Vartanian - Littleton MA
An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.
Apparatus And Methods For Verifying The Location Of Areas Of Interest Within A Sample In An Imaging System
David J. Zahniser - Wellesley MA, US Theodore S. Geiselman - Bolton MA, US
Assignee:
Cytyc Corporation - Marlborough MA
International Classification:
G06K 9/00
US Classification:
382128, 382287, 382291, 702 95
Abstract:
An apparatus and method for verifying the location of an area of interest within a sample are disclosed. An imaging system includes an optical system and a stage movable relative to the optical system. A computer server is in communication with the imaging system and with a review station. The imaging system is capable of spatially locating a datum mark on the sample and determining a spatial offset value of the mark relative to a nominal position thereof. The coordinate systems of a respective one of the imaging system and the review station can be standardized. The method includes locating a datum mark on the sample, and identifying an area of interest within the sample. The method further includes determining the location of the area of interest relative to the mark. The method further includes locating again the datum, and checking that a dimensional error in locating the datum mark is less than a tolerance value to verify location of the area of interest.
Method And Apparatus For Preparing Cytological Specimens
Roy A. Ostgaard - Bolton MA, US Lewis A. Capriccio - Westford MA, US Theodore S. Geiselman - Bolton MA, US Robert E. Jennings - Andover MA, US Bruce Levkoff - Sharon MA, US Edward O'Connell - Medford MA, US Douglas A. Tenney - North Reading MA, US Hugh Vartanian - Littleton MA, US
Assignee:
Cytyc Corporation - Marlborough MA
International Classification:
G01N 35/00 G01B 5/16 G06K 9/00
US Classification:
436 43, 73156, 382128
Abstract:
An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.
Method And Apparatus For Preparing Cytological Specimens
An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.
Method And Apparatus For Preparing Cytological Specimens
Roy A. Ostgaard - Bolton MA, US Theodore S. Geiselman - Bolton MA, US
Assignee:
Cytyc Corporation - Marlborough MA
International Classification:
G01N 33/00
US Classification:
436 43, 436172
Abstract:
An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.
David Zahniser - Wellesley MA, US Theodore Geiselman - Bolton MA, US Roy Ostgaard - Marion NC, US James Woodard - Powell OH, US Kenneth Scott - Westerville OH, US Scott Danhof - Plain City OH, US Jan Yates - Reynoldsburg OH, US Larry Schluer - Sugar Grove OH, US Joseph Zambanini - Delaware OH, US Joseph Juratovac - Columbus OH, US Matthew Zelinski - Worthington OH, US James Mank - Dublin OH, US Michael Ulrich - Columbus OH, US Howard Greene - Worthington OH, US Randal Chinnock - Southbridge MA, US Thomas Haubert - Columbus OH, US
Assignee:
Cytyc Corporation - Marlborough MA
International Classification:
G02B 21/00
US Classification:
359368000
Abstract:
The present invention relates to the analysis of specimens. Specifically, the invention relates to methods and apparatus for reviewing specimen slides, including apparatus for holding the slides. The invention also relates to an automatic focusing method for an imaging system and methods for accommodating vibration in the imaging system. In particular, the methods and apparatus may be applied to the automated analysis of cytological specimen slides.
David Zahniser - Wellesley MA, US Theodore Geiselman - Bolton MA, US Roy Ostgaard - Marion NC, US Howard Greene - Worthington OH, US Joseph Zambanini - Delaware OH, US Joseph Juratovac - Columbus OH, US Matthew Zelinski - Worthington OH, US Scott Danhof - Plain City OH, US Eric Hassenpflug - Westerville OH, US Thomas Haubert - Columbus OH, US Randal Chinnock - Southbridge MA, US
Assignee:
Cytyc Corporation - Marlborough MA
International Classification:
G02B 21/34
US Classification:
359396000
Abstract:
The present invention relates to the analysis of specimens. Specifically, the invention relates to methods and apparatus for reviewing specimen slides, including apparatus for holding the slides. The invention also relates to an automatic focusing method for an imaging system and methods for accommodating vibration in the imaging system. In particular, the methods and apparatus may be applied to the automated analysis of cytological specimen slides.