Teresa Tang Chan

US Patent:

7939283, May 10, 2011

Filed:

Jul 12, 2002

Appl. No.:

10/194638

Inventors:

Teresa Chan - Wayland MA, US
Joseph F. Lawlor - Arlington MA, US
Gordon C. Siek - Somerville MA, US
Arleen Chase - Billerica MA, US
Joseph D. Musto - Dover MA, US

Assignee:

Fisher Scientific Company L.L.C. - Pittsburgh PA

International Classification:

G01N 33/53
G01N 33/543

US Classification:

435 75, 435 71, 435 794, 435 792, 435 4, 436518, 436523, 436525, 436528

Abstract:

Assays, such as immunoassays, and related articles are disclosed.

US Patent:

43116906, Jan 19, 1982

Filed:

Jun 14, 1979

Appl. No.:

6/048628

Inventors:

Robert J. Buehler - Holliston MA
Teresa H. Chan - Burlington MA
Franklin Lim - Richmond VA

Assignee:

Damon Corporation - Needham Heights MA

International Classification:

G01N 3356
A61K 4300
B01J 1302

US Classification:

424 1

Abstract:

Disclosed is a process for determining the concentration of unbound hormone, e. g. , thyroxine, cortisol, or testosterone, in a liquid sample containing hormone and protein capable of binding the hormone. The sample is incubated with antibody specific to the hormone to be detected and a distinguishable analogue of the hormone, both of which are separated from the sample by semipermeable membranes capable of excluding the passage of natural protein and antibody but which allow passage of the hormone and its analogue. Preferably, the antibody and analogue are contained in semipermeable microcapsules. Free hormone in the sample permeates the membranes and competes for sites of attachment to the antibody with the analogue. The antibody and free hormones are then separated. The amount of analogue present either in association with the antibody or in the remainder of the reaction system is indicative of the level of free hormone originally present in the sample.

US Patent:

47313269, Mar 15, 1988

Filed:

Jun 4, 1984

Appl. No.:

6/616991

Inventors:

Russell E. Thompson - Marshfield MA
Robert H. Rubin - Brookline MA
Nina T. Rubin - Brookline MA
Teresa H. Chan - Burlington MA

Assignee:

Ortho Diagnostic Systems Inc. - Raritan NJ

International Classification:

G01N 33535
G01N 33545
G01N 33574
G01N 33577

US Classification:

435 7

Abstract:

Methods are provided for the detection of proximal convoluted tubule causing diseases or kidney harmful drug monitoring by detecting the presence of shed normal proximal tubule associated antigens in a body fluid such as urine. The preferred embodiment employs an ELISA sandwich format wherein one monoclonal antibody specific for a first epitopic site on said antigen is immobilized on a solid phase and a second antibody, specific for a second epitopic site on said antigen is directly or indirectly labeled.

US Patent:

47910674, Dec 13, 1988

Filed:

Jun 25, 1987

Appl. No.:

7/066306

Inventors:

Mark I. Sheiman - Nanuet NY
Kwok K. Yeung - Suffern NY
Teresa H. Chan - Wayland MA

Assignee:

Fisher Scientific Co. - Pittsburgh PA

International Classification:

G01N 33546
G01N 33577

US Classification:

436513

Abstract:

An assay method and kit for a hapten such as theophylline employs a first, latex reagent and a second, antibody reagent. By using a monoclonal antibody of the IgA class in the second reagent, interference by patient rheumatoid factor is prevented.