Teresa Cheeks Wilson

US Patent:

20080138433, Jun 12, 2008

Filed:

Oct 31, 2007

Appl. No.:

11/930972

Inventors:

Olaf Fritz - Hirschhorn, DE
Ulf Fritz - Hirschhorn, DE
Roman Denk - Weidenstetten, DE
Teresa Wilson - Newnan GA, US
Ralph E. Gaskins - Atlanta GA, US

Assignee:

CELONOVA BIOSCIENCES, INC. - Newnan GA

International Classification:

A61K 35/14
C12M 1/00
A61L 27/34
A61L 27/54

US Classification:

424529, 4353071, 5147723

Abstract:

The present invention is directed to medical devices including blood storage and handling products that comprise a specific polyphosphazene and the capability of releasing nitric oxide or other smooth muscle relaxant compounds in vivo or into stored or transient flowing blood to achieve vascular dilatation, reduced adverse reactions, reduced thrombosis, reduced incidence of post-transfusion acute myocardial infarctions, and/or to improve blood storage capabilities.

US Patent:

20080138792, Jun 12, 2008

Filed:

Oct 31, 2007

Appl. No.:

11/931021

Inventors:

Olaf Fritz - Hirschhorn, DE
Ulf Fritz - Hirschhorn, DE
Roman Denk - Weidenstetten, DE
Teresa Wilson - Newnan GA, US
Ralph E. Gaskins - Atlanta GA, US

Assignee:

CELONOVA BIOSCIENCES, INC. - Newnan GA

International Classification:

A61L 27/54
C12M 1/00
A01N 1/02
A61L 27/34

US Classification:

435 2, 4353071, 523113, 424426

Abstract:

The present invention is directed to medical devices in which flow is channeled of blood and blood products for the purpose of effecting a chemical exchange to remove desired chemicals from the blood or blood products, and to impart nitric oxide, other smooth muscle relaxant compounds, or other desired chemicals to the blood or blood products to achieve vascular dilatation, reduce adverse reactions, reduce thrombosis, reduce red blood cell injuries, and improve blood handling capabilities. In the present invention, such chemical exchanges occur over semipermeable membranes associated with channeled flow of blood and blood products. Various embodiments of the present invention thus apply to the clinical settings for filters, cannulae, tubing, and blood handling components for dynamic blood handling, filtering, and processing devices including, but not limited to, cardiopulmonary bypass pumps, left ventricular assist devices, artificial hearts, ECMO devices, renal or hepatic hemodialysis systems, and hemofiltration systems.

US Patent:

20090110738, Apr 30, 2009

Filed:

Oct 26, 2007

Appl. No.:

11/924728

Inventors:

Thomas A. Gordy - Newnan GA, US
Olaf Fritz - Hirschhorn, DE
Ulf Fritz - Hirschhorn, DE
Ronald Wojcik - Canton GA, US
Teresa Wilson - Newnan GA, US
Harry R. Jacobson - Nashville TN, US

Assignee:

CELONOVA BIOSCIENCES, INC. - Newnan GA

International Classification:

A61K 9/00
A61K 47/30
A61K 9/14
A61P 17/00

US Classification:

424490, 424484, 5147723

Abstract:

Particles are provided for use in therapeutic cosmetic and/or reconstructive procedures to augment defects in tissue to restore contours and/or function. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired tissues. Moreover, such particles may be loaded to provide localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided or used in conjunction with tissue adhesives or photoinitiator agents that may be activated by electromagnetic radiation or other energy sources to allow post-implantation cross-linking of the polymeric particles to cause their amalgamation to maintain their shape and location following implantation.

US Patent:

20080138377, Jun 12, 2008

Filed:

Oct 31, 2007

Appl. No.:

11/930737

Inventors:

Olaf Fritz - Hirschhorn, DE
Ulf Fritz - Hirschhorn, DE
Roman Denk - Weidenstetten, DE
Teresa Wilson - Newnan GA, US
Ralph E. Gaskins - Atlanta GA, US

Assignee:

CELONOVA BIOSCIENCES, INC. - Newnan GA

International Classification:

A61K 9/00
A61K 47/16

US Classification:

424423, 514788

Abstract:

The present invention is directed to luminal stent devices including vascular devices that comprise a specific polyphosphazene and the capability of releasing nitric oxide or other smooth muscle relaxant compounds in vivo or into stored or transient flowing blood to achieve vascular dilatation, reduce adverse reactions, reduce thrombosis, and/or to maintain the patency of a desired anatomic lumen.