Terrence A Green

US Patent:

6482309, Nov 19, 2002

Filed:

Oct 19, 2000

Appl. No.:

09/694110

Inventors:

Terrence R. Green - Lake Oswego OR
Jack H. Fellman - McMinnville OR

Assignee:

OxiBio, Inc. - Portland OR

International Classification:

C25B 124

US Classification:

205619, 205701, 204242, 204260, 204272

Abstract:

An anti-infective device generally comprising an oxidant generating formulation contained within at least a section of the device configured to electrolytically generate an anti-infective oxidant. The device has at least one of a cathode member and an anode member in the section of the device, configured to electrolyze the oxidant generating formulation to electrolytically generate the anti-infective oxidant. A power source is electrically connected to the cathode and anode members such that current passes between the cathode and anode members. In one embodiment, the oxidant generating formulation comprises a solid dispersed in a polymeric wall of the device. In a presently preferred embodiment, the cathode and anode members are completely embedded within the polymeric wall of the device, although in some embodiments they may be partially embedded within the polymeric wall of the device. In another embodiment, the oxidant generating formulation comprises a solution contained within a chamber in the device. The cathode and anode members are located within the chamber in contact with the solution.

US Patent:

6592890, Jul 15, 2003

Filed:

Oct 19, 2000

Appl. No.:

09/694104

Inventors:

Terrence R. Green - Lake Oswego OR

Assignee:

OxiBio, Inc. - Portland OR

International Classification:

A61L 1516

US Classification:

424447, 424445, 424 944, 424667, 424669

Abstract:

A wound dressing having anti-infective activity. The wound dressing provides stable and improved formulations of precursors required in generating anti-infective iodine specifically within a wound site where the oxygen tension may be very low. Furthermore, the design of the invention precludes interference by catalase (and other heme proteins. ) in competing for hydrogen peroxide where hydrogen peroxide is used as a component of the iodine generating formulation, ensuring more efficient and sustained production of free iodine as a potent anti-infective agent. The invention takes advantage of the physical design of the wound dressing, and the permeation of body fluid into the dressing, which together serve to initiate formation of nascent iodine concomitant with placement of the dressing into, or over, a wound site. The invention circumvents the problem of trapping elemental iodine in the form of tri-iodide, which lacks microbicidal activity, by the chemical method of generating iodine de novo, and in the presence of excess oxidant. Newly formed iodine is thus able to egress and disperse throughout the wound site before there is an opportunity for it to become fully bound as tri-iodide, conferring to the wound site anti-infective activity.

US Patent:

6838050, Jan 4, 2005

Filed:

Jun 2, 2000

Appl. No.:

09/585911

Inventors:

Terrence R. Green - Lake Oswego OR, US
Jack Fellman - McMinville OR, US

Assignee:

Oxibio, Inc. - Portland OR

International Classification:

A61L 200

US Classification:

422 37, 12820714

Abstract:

Methods of providing anti-infective activity to a medical device including the steps of exposing the medical device to an anti-infective oxidant, and transferring the anti-infective oxidant into a wall of the medical device. One embodiment includes the step of exposing a medical device that is at least in part within a patient to the anti-infective oxidant. Another embodiment includes the steps of exposing a medical device to an aqueous solution which produces the anti-infective oxidant and transferring a sufficient amount of the anti-infective oxidant into the medical device wall to provide the medical device with anti-infective activity. Also provided is an oxidant releasing member that has anti-infective oxidant releasably contained therein and that is configured to be disposed adjacent to the medical device. Exemplary devices include catheters such as venous, arterial, and urinary catheters, generally containing an elongated catheter shaft having a lumen extending therein, and optionally having a balloon on the shaft in fluid communication with the catheter lumen.

US Patent:

6939569, Sep 6, 2005

Filed:

Jun 18, 1999

Appl. No.:

09/336392

Inventors:

Terrence R. Green - Lake Oswego OR, US
Jack Fellman - McMinnville OR, US

Assignee:

Oxibio, Inc. - Portland OR

International Classification:

A61K033/08
A61K031/19
A61K033/40
A01N025/00

US Classification:

424667, 424405, 424409, 424422, 424423, 424486, 424668, 424669, 424670, 424671, 514557, 5147723, 514953

Abstract:

There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to confer to the site microbicidal or virucidal activity. Devices in the disclosure designed as vaginal inserts also exhibit contraceptive spermicidal activity. The coated devices or devices having the inventive polymeric material interspersed throughout are formed into appropriate shapes according to their contemplated uses (such as catheters or Foley catheters). Further, the present invention provides devices for providing therapeutic anti-microbial activity into an infected body cavity or on an infected wound site.

US Patent:

20120187041, Jul 26, 2012

Filed:

Jan 20, 2011

Appl. No.:

13/010654

Inventors:

Radu Popa - Portland OR, US
Terrence R. Green - Lake Oswego OR, US

International Classification:

C02F 3/32
C02F 1/58
A01K 67/00

US Classification:

210602, 119 65, 2101981, 210 85, 210177, 210188

Abstract:

Disclosed herein are methods of removing organic solutes from liquids. The methods include incubating fly larvae with a liquid that contains organic solutes. Also disclosed herein are methods of producing larva biomass. Additionally, apparatus for use with the disclosed methods are described.