Theresa Ann Deisher

US Patent:

6352971, Mar 5, 2002

Filed:

Aug 5, 1999

Appl. No.:

09/368951

Inventors:

Theresa A. Deisher - Seattle WA
Darrell C. Conklin - Seattle WA
Fenella Raymond - Seattle WA
Thomas R. Bukowski - Seattle WA
Susan D. Holderman - Kirkland WA
Birgit Hansen - Seattle WA
Paul O. Sheppard - Redmond WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 3800

US Classification:

514 2, 435 71, 530350, 5303871, 4241921

Abstract:

The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.

US Patent:

6420521, Jul 16, 2002

Filed:

Jun 30, 2000

Appl. No.:

09/608810

Inventors:

Paul O. Sheppard - Granite Falls WA
Stephen R. Jaspers - Edmonds WA
Theresa A. Deisher - Seattle WA
Paul D. Bishop - Fall City WA

Assignee:

Zymogenetics, Inc. - Seattle WA

International Classification:

G01N 3353

US Classification:

530328, 435 71, 435 721, 435 76, 435198, 530329, 530330, 514 15

Abstract:

The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel Short Gastrointestinal Peptides (SGIP) peptide.

US Patent:

6420525, Jul 16, 2002

Filed:

Aug 19, 1998

Appl. No.:

09/137223

Inventors:

David P. Yee - Seattle WA
Theresa A. Deisher - Seattle WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 1447

US Classification:

530350

Abstract:

Novel ZGCL-1 transcription factor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides, agonists and antagonists may be used within methods for promoting the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

US Patent:

6486304, Nov 26, 2002

Filed:

Mar 10, 2000

Appl. No.:

09/523462

Inventors:

Theresa A. Deisher - Seattle WA
Paul O. Sheppard - Redmond WA

Assignee:

Zymogenetics, Inc. - Seattle WA

International Classification:

C07K 1600

US Classification:

5303891, 5303892, 53038815, 53038824, 4241341, 4241391, 4241451, 514 2, 514 12

Abstract:

The present invention relates to polynucleotide and polypeptide molecules for zsig45, a novel human protein expressed in thyroid. The polypeptides, and polynucleotides encoding them, may be used for detecting human disease states and chromosomal abnormalities, and as a therapeutic. The present invention also includes antibodies to the zsig45 polypeptides.

US Patent:

6500925, Dec 31, 2002

Filed:

Mar 10, 2000

Appl. No.:

09/522980

Inventors:

Theresa A. Deisher - Seattle WA
Paul O. Sheppard - Redmond WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 100

US Classification:

530350, 530300, 530399, 424520, 424562, 424568, 435 694, 435 697, 436500

Abstract:

The present invention relates to polynucleotide and polypeptide molecules for zsig45, a novel human protein expressed in thyroid. The polypeptides, and polynucleotides encoding them, may be used for detecting human disease states and chromosomal abnormalities, and as a therapeutic. The present invention also includes antibodies to the zsig45 polypeptides.

US Patent:

6518236, Feb 11, 2003

Filed:

Jan 13, 1999

Appl. No.:

09/229947

Inventors:

Theresa A. Deisher - Seattle WA
Darrell C. Conklin - Seattle WA
Fenella Raymond - Seattle WA
Thomas R. Bukowski - Seattle WA
Susan D. Holderman - Seattle WA
Birgit Hansen - Seattle WA
Paul O. Sheppard - Redmond WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 1450

US Classification:

514 2, 514 12, 530350, 530399, 435 697

Abstract:

The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.

US Patent:

6627729, Sep 30, 2003

Filed:

Sep 23, 1999

Appl. No.:

09/404417

Inventors:

Paul O. Sheppard - Redmond WA
Theresa A. Deisher - Seattle WA
Stephen R. Jaspers - Edmonds WA
Paul D. Bishop - Fall City WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 706

US Classification:

530326, 530327, 530328, 530309

Abstract:

The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.

US Patent:

6838438, Jan 4, 2005

Filed:

Feb 27, 2001

Appl. No.:

09/794987

Inventors:

Paul O. Sheppard - Granite Falls WA, US
Theresa A. Deisher - Seattle WA, US
Paul D. Bishop - Fall City WA, US
Stephen R. Jaspers - Edmonds WA, US
Virender M. Labroo - Mill Creek WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 3810
C07K 708
C07K 1463

US Classification:

514 13, 514 14, 530326, 530327

Abstract:

The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.