Theresa M Erickson

US Patent:

6387379, May 14, 2002

Filed:

Feb 28, 1994

Appl. No.:

08/202647

Inventors:

Eugene P. Goldberg - Gainesville FL
Ali Yahiaoui - Roswell GA
Khalid Mentak - Goleta, MA
Theresa Rivero Erickson - Salt Lake City UT
James Seeger - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

A61L 2716

US Classification:

424400, 427492, 427495, 427496, 427498, 427507, 427535, 427536, 427539, 427491, 427 21, 427 212, 606151, 606159, 604 93, 623 8, 523106

Abstract:

A method for modifying the surface of a material adapted for contact with tissue of a human or non-human animal to impart biofunctional, bioactive or biomimetic properties to the surface comprising: (a) exposing the surface to a solution comprising (1) an ethylenically unsaturated monomer or mixture thereof capable, via the ethylenic unsaturation, of gamma irradiation or electron beam induced polymerization, and (2) at least one biofunctional agent; and (b) irradiating the surface with gamma or electron beam irradiation in the presence of the solution to thereby form on the surface a graft polymerized coating, the coating having physically entrapped therein or chemically bonded thereto molecules of the at least one biofunctional agent which imparts biofunctional or biomimetic properties to the surface; wherein the gamma or electron beam irradiation induced polymerization is conducted under one of the following conditions: A. (i) monomer concentration in the solution in the range of from about 0. 1% to about 50%, by weight; (ii) total gamma or electron beam dose in the range of from about 0.