Thomas P Budinger

US Patent:

6426058, Jul 30, 2002

Filed:

Mar 28, 1997

Appl. No.:

08/825475

Inventors:

Alexander Pines - Berkeley CA
Thomas Budinger - Berkeley CA
Gil Navon - Ramat Gan, IL
Stephan Appelt - Berkeley CA
Angelo Bifone - Rome, IT
Rebecca Taylor - Berkeley CA
Boyd Goodson - Berkeley CA
Roberto Seydoux - Berkeley CA
Toomas Room - Albany CA
Tanja Pietrass - Socorro NM

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 505

US Classification:

424 93, 424 937, 436173, 600410, 600420

Abstract:

The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e. g. , Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

US Patent:

6818202, Nov 16, 2004

Filed:

Jun 5, 2002

Appl. No.:

10/164324

Inventors:

Alexander Pines - Berkeley CA
Thomas Budinger - Berkeley CA
Gil Navon - Ramat Gan, IL
Stephan Appelt - Waiblingen, DE
Angelo Bifone - Rome, IT
Rebecca Taylor - Berkeley CA
Boyd Goodson - Berkeley CA
Roberto Seydoux - Berkeley CA
Toomas Room - Albany CA
Tanja Pietrass - Socorro NM

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 5055

US Classification:

424 93, 424 937, 436173, 600410, 600420

Abstract:

The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e. g. , Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

US Patent:

7385395, Jun 10, 2008

Filed:

Sep 13, 2004

Appl. No.:

10/940297

Inventors:

Alexander Pines - Berkeley CA, US
Thomas Budinger - Berkeley CA, US
Gil Navon - Ramat Gan, IL
Stephan Appelt - Waiblingen, DE
Angelo Bifone - Rome, IT
Rebecca Taylor - Berkeley CA, US
Boyd Goodson - Berkeley CA, US
Roberto Seydoux - Berkeley CA, US
Toomas Room - Albany CA, US
Tanja Pietrass - Socorro NM, US

Assignee:

Lawrence Berkeley National Laboratory - Berkeley CA

International Classification:

G01V 3/00
G01N 24/00
A61B 5/055

US Classification:

324301, 324307, 436173, 424 93

Abstract:

The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e. g. , Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

US Patent:

7535229, May 19, 2009

Filed:

Apr 26, 2007

Appl. No.:

11/740772

Inventors:

Ross D. Schlueter - Berkeley CA, US
Thomas F. Budinger - Berkeley CA, US

International Classification:

G01V 3/00

US Classification:

324318, 324307, 324309, 324310, 324319, 324321

Abstract:

Disclosed herein are systems and methods for generating a rotating magnetic field. The rotating magnetic field can be used to obtain rotating-field NMR spectra, such as magic angle spinning spectra, without having to physically rotate the sample. This result allows magic angle spinning NMR to be conducted on biological samples such as live animals, including humans.

US Patent:

20060264755, Nov 23, 2006

Filed:

Feb 23, 2006

Appl. No.:

11/362326

Inventors:

Jonathan Maltz - Oakland CA, US
Thomas Budinger - Berkeley CA, US

International Classification:

A61B 8/00

US Classification:

600455000, 600437000

Abstract:

A “relaxoscope” () detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxafion. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse () at a superficial radial artery () via a linear actuator (). An ultrasonic Doppler stethoscope () detects this pulse 10-20 cm proximal to the point of pulse induction (). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before () and after arterial diameter change (), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

US Patent:

20100198063, Aug 5, 2010

Filed:

Nov 19, 2009

Appl. No.:

12/622335

Inventors:

Jennifer S. Huber - El Sobrante CA, US
William W. Moses - Berkeley CA, US
Jean Pouliot - Mill Valley CA, US
Qiyu Peng - Albany CA, US
Ronald H. Huesman - Danville CA, US
Thomas F. Budinger - Berkeley CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61B 8/00
G09B 23/30
G01T 1/164

US Classification:

600437, 434267, 25036303

Abstract:

Herein are described methods and tools for acquiring accurately co-registered PET and TRUS images, as well as the construction and use of PET-TRUS prostate phantoms. Ultrasound imaging with a transrectal probe provides anatomical detail in the prostate region that can be accurately co-registered with the sensitive functional information from the PET imaging. Imaging the prostate with both PET and transrectal ultrasound (TRUS) will help determine the location of any cancer within the prostate region. This dual-modality imaging should help provide better detection and treatment of prostate cancer. Multi-modality phantoms are also described.

US Patent:

44737491, Sep 25, 1984

Filed:

Jan 29, 1982

Appl. No.:

6/344161

Inventors:

Stephen E. Derenzo - Pinole CA
Thomas F. Budinger - Berkeley CA

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

G01T 120

US Classification:

250363S

Abstract:

In brief, the invention is a tomograph modified to be in a clamshell configuration so that the ring or rings may be moved to multiple sampling positions. The tomograph includes an array of detectors arranged in successive adjacent relative locations along a closed curve in a first position in a selected plane, and means for securing the detectors in the relative locations in a first sampling position. The securing means is movable in the plane in two sections and pivotable at one p The U. S. Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the U. S. Department of Energy and the University of California.