Thomas J Chen

US Patent:

7799012, Sep 21, 2010

Filed:

Jul 10, 2009

Appl. No.:

12/501012

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Leslie Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US
Thomas C. Chen - La Canada CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61M 31/00

US Classification:

604508, 604506, 604507, 604509, 6048901

Abstract:

A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

US Patent:

7799016, Sep 21, 2010

Filed:

Jun 20, 2008

Appl. No.:

12/143720

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Thomas C. Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61K 9/22

US Classification:

6048911, 6048901, 604 65, 604 66, 604 67, 604508

Abstract:

A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

US Patent:

7981917, Jul 19, 2011

Filed:

Mar 26, 2008

Appl. No.:

12/056192

Inventors:

Axel H. Schönthal - Los Angeles CA, US
Nicos A. Petasis - Hacienda Heights CA, US
Florence M. Hofman - Venice CA, US
Stan G. Louie - Fullerton CA, US
Thomas C. Chen - La Canada CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/415

US Classification:

514406, 514256

Abstract:

The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

US Patent:

8133172, Mar 13, 2012

Filed:

Dec 23, 2008

Appl. No.:

12/343436

Inventors:

Josh Shachar - Santa Monica CA, US
Thomas Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Winston Wu - Alhambra CA, US
Kyle Zimmerman - Los Angeles CA, US
Moran Cerf - Los Angeles CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61B 1/32

US Classification:

600202, 600544

Abstract:

Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs.

US Patent:

8145434, Mar 27, 2012

Filed:

Apr 10, 2009

Appl. No.:

12/422125

Inventors:

Josh Yehoshua Shachar - Santa Monica CA, US
Winston H. Wu - Alhambra CA, US
Leslie Farkas - Ojai CA, US
Thomas Chen - La Canada CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

G06F 11/00

US Classification:

702 19

Abstract:

A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip. The device has an array of parallel capacitors which act as an integrated, individual counter-electrode, computational apparatus which employs the sensory output over the time domain so as to enable detection, reporting and formation of a homeostatic loop for VEGF measurements.

US Patent:

8236862, Aug 7, 2012

Filed:

Feb 4, 2010

Appl. No.:

12/700614

Inventors:

Thomas C. Chen - Los Angeles CA, US
Clovis O. da Fonseca - Rio de Janeiro, BR
Thereza Quirico dos Santos - Niterói, BR
Gilberto Schwartsmann - Porto Alegre, BR

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/045

US Classification:

514729, 514724, 554229

Abstract:

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

US Patent:

8323269, Dec 4, 2012

Filed:

Oct 19, 2009

Appl. No.:

12/581756

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Thomas C. Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61K 9/22

US Classification:

6048911

Abstract:

A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled lumen, intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

US Patent:

8323270, Dec 4, 2012

Filed:

Oct 19, 2009

Appl. No.:

12/581770

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Thomas C. Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61K 9/22

US Classification:

6048911

Abstract:

A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents mixed with Avastin at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, the medicating agent Avastin is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. In cases where a tumor resection is not performed, an intratumoral catheter will be implanted. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.