Thomas L Chen

US Patent:

7981917, Jul 19, 2011

Filed:

Mar 26, 2008

Appl. No.:

12/056192

Inventors:

Axel H. Schönthal - Los Angeles CA, US
Nicos A. Petasis - Hacienda Heights CA, US
Florence M. Hofman - Venice CA, US
Stan G. Louie - Fullerton CA, US
Thomas C. Chen - La Canada CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/415

US Classification:

514406, 514256

Abstract:

The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

US Patent:

8236862, Aug 7, 2012

Filed:

Feb 4, 2010

Appl. No.:

12/700614

Inventors:

Thomas C. Chen - Los Angeles CA, US
Clovis O. da Fonseca - Rio de Janeiro, BR
Thereza Quirico dos Santos - Niterói, BR
Gilberto Schwartsmann - Porto Alegre, BR

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/045

US Classification:

514729, 514724, 554229

Abstract:

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

US Patent:

8507734, Aug 13, 2013

Filed:

Mar 3, 2011

Appl. No.:

13/040059

Inventors:

Thomas Chen - La Canada CA, US
Daniel Levin - La Canada CA, US
Satish Puppali - Glendora CA, US

Assignee:

Neonc Technologies Inc. - Inglewood CA

International Classification:

C07C 27/26

US Classification:

568854, 568875, 556437

Abstract:

The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98. 5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98. 5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

US Patent:

20070183155, Aug 9, 2007

Filed:

Feb 8, 2007

Appl. No.:

11/704737

Inventors:

Thomas Chen - Chino CA, US

International Classification:

F21V 23/04

US Classification:

362276

Abstract:

A decorative entertaining unit includes a decorative ornament body and an entertaining unit. The decorative ornament body has a base portion attached on a user's body, and a decorative portion extended from the base portion, wherein the decorative portion has a predetermined aesthetic appearance for serving general decorative function. The entertaining unit is embedded into the decorative ornament body, and comprises an illuminating unit adapted to operate between a normal mode and an enhanced decoration mode, wherein in the normal mode, the illuminating unit is deactivated to allow plain decoration from the decorative ornament body, wherein in the enhanced decoration mode, the illuminating unit is activated to generate a predetermined pattern of illumination so as to provide an illuminating decorative effect of the decorative ornament body.

US Patent:

20100234669, Sep 16, 2010

Filed:

Mar 11, 2009

Appl. No.:

12/402437

Inventors:

Kevin Armstrong - Irvine CA, US
Thomas Chen - La Canada CA, US

International Classification:

A61M 36/12

US Classification:

600 7

Abstract:

There is provided herein a brachytherapy delivery system for the internal delivery and positioning of therapeutic agent, most particularly, a discrete radiation emitting particulate, within or in proximity to a vertebral or other bony tumor. The system comprises an elongated bone cannula having a proximal and a distal end, the distal end being suitable for disposition within bone. The bone cannula further comprises a bore disposed longitudinally therethrough suitable to axially and slidably receive an elongated and cannulated therapy delivery apparatus through which the therapeutic agent is delivered.

US Patent:

20120219541, Aug 30, 2012

Filed:

May 10, 2012

Appl. No.:

13/468970

Inventors:

Thomas C. Chen - Los Angeles CA, US
Clovis O. da Fonseca - Rio de Janeiro, BR
Thereza Quirico dos Santos - Niteroi, BR
Gilberto Schwartsmann - Porto Alegre, BR

International Classification:

A61K 39/395
A61K 47/14
A61P 35/04
A61K 31/415
A61P 25/00
A61P 35/00
A61K 47/10
A61K 31/4188

US Classification:

4241301, 514772, 514785, 514393, 514406

Abstract:

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

US Patent:

20130203828, Aug 8, 2013

Filed:

Aug 3, 2012

Appl. No.:

13/566731

Inventors:

Thomas Chen - La Canada CA, US
Daniel Levin - La Canada CA, US

Assignee:

NEO ONCOLOGY INC. - Woodland Hills CA

International Classification:

A61K 47/48
A61N 5/10
A61K 45/06

US Classification:

514393, 544179, 600 1

Abstract:

The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

US Patent:

20130210877, Aug 15, 2013

Filed:

Aug 26, 2011

Appl. No.:

13/818972

Inventors:

Thomas Chen - La Canada CA, US
Daniel Levin - La Canada CA, US
Satish Puppali - Rancho Cucamonga CA, US

Assignee:

NEONC TECHNOLOGIES INC. - Inglewood CA

International Classification:

C07D 487/04
C07D 207/26
C07D 231/12

US Classification:

514393, 5483771, 514406, 5483031, 548531, 514423

Abstract:

The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.