Thomas J Chen

US Patent:

7981917, Jul 19, 2011

Filed:

Mar 26, 2008

Appl. No.:

12/056192

Inventors:

Axel H. Schönthal - Los Angeles CA, US
Nicos A. Petasis - Hacienda Heights CA, US
Florence M. Hofman - Venice CA, US
Stan G. Louie - Fullerton CA, US
Thomas C. Chen - La Canada CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/415

US Classification:

514406, 514256

Abstract:

The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

US Patent:

8236862, Aug 7, 2012

Filed:

Feb 4, 2010

Appl. No.:

12/700614

Inventors:

Thomas C. Chen - Los Angeles CA, US
Clovis O. da Fonseca - Rio de Janeiro, BR
Thereza Quirico dos Santos - Niterói, BR
Gilberto Schwartsmann - Porto Alegre, BR

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/045

US Classification:

514729, 514724, 554229

Abstract:

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

US Patent:

20070183155, Aug 9, 2007

Filed:

Feb 8, 2007

Appl. No.:

11/704737

Inventors:

Thomas Chen - Chino CA, US

International Classification:

F21V 23/04

US Classification:

362276

Abstract:

A decorative entertaining unit includes a decorative ornament body and an entertaining unit. The decorative ornament body has a base portion attached on a user's body, and a decorative portion extended from the base portion, wherein the decorative portion has a predetermined aesthetic appearance for serving general decorative function. The entertaining unit is embedded into the decorative ornament body, and comprises an illuminating unit adapted to operate between a normal mode and an enhanced decoration mode, wherein in the normal mode, the illuminating unit is deactivated to allow plain decoration from the decorative ornament body, wherein in the enhanced decoration mode, the illuminating unit is activated to generate a predetermined pattern of illumination so as to provide an illuminating decorative effect of the decorative ornament body.

US Patent:

20100234669, Sep 16, 2010

Filed:

Mar 11, 2009

Appl. No.:

12/402437

Inventors:

Kevin Armstrong - Irvine CA, US
Thomas Chen - La Canada CA, US

International Classification:

A61M 36/12

US Classification:

600 7

Abstract:

There is provided herein a brachytherapy delivery system for the internal delivery and positioning of therapeutic agent, most particularly, a discrete radiation emitting particulate, within or in proximity to a vertebral or other bony tumor. The system comprises an elongated bone cannula having a proximal and a distal end, the distal end being suitable for disposition within bone. The bone cannula further comprises a bore disposed longitudinally therethrough suitable to axially and slidably receive an elongated and cannulated therapy delivery apparatus through which the therapeutic agent is delivered.

US Patent:

20120219541, Aug 30, 2012

Filed:

May 10, 2012

Appl. No.:

13/468970

Inventors:

Thomas C. Chen - Los Angeles CA, US
Clovis O. da Fonseca - Rio de Janeiro, BR
Thereza Quirico dos Santos - Niteroi, BR
Gilberto Schwartsmann - Porto Alegre, BR

International Classification:

A61K 39/395
A61K 47/14
A61P 35/04
A61K 31/415
A61P 25/00
A61P 35/00
A61K 47/10
A61K 31/4188

US Classification:

4241301, 514772, 514785, 514393, 514406

Abstract:

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

US Patent:

41061063, Aug 8, 1978

Filed:

Mar 16, 1976

Appl. No.:

5/667338

Inventors:

Ronald G. Wolfshagen - Newport Beach CA
John E. Ypma - Anaheim CA
Glen W. Murray - Irvine CA
Thomas T. Chen - Yorba Linda CA

Assignee:

Rockwell International Corporation - El Segundo CA

International Classification:

G11C 1908

US Classification:

365 2

Abstract:

A unique and compact open coil rotating magnetic field network structure to efficiently package an array of bubble domain devices is disclosed. The field network has a configuration which effectively enables selected bubble domain devices from the array to be driven in a vertical magnetic field and in an independent and uniform horizontal rotating magnetic field. The field network is suitably adapted to minimize undesirable inductance effects, improve capabilities of heat dissipation, and facilitate repair or replacement of a bubble device.

US Patent:

40965805, Jun 20, 1978

Filed:

Jul 26, 1976

Appl. No.:

5/708806

Inventors:

Thomas T. Chen - Yorba Linda CA

Assignee:

Rockwell International Corporation - El Segundo CA

International Classification:

G11C 1908

US Classification:

365 1

Abstract:

This invention relates to an improved network and technique for correcting bubble domain memories of the major/minor loop type. In particular, a selectively insertable correction loop can be provided in a major loop path to insert or remove blank bits so that the effect of defective minor loops can be overcome. The correction networks include propagation loops formed of conventional magnetic bubble domain device elements and a conductor which is selectively alterable to provide a bypass or insertion mode of operation for the correction loop relative to the major loop.

US Patent:

60539577, Apr 25, 2000

Filed:

Jul 24, 1998

Appl. No.:

9/121410

Inventors:

Thomas Chen - Cerritos CA

Assignee:

ATT Environmental Technology Inc. - Cypress CA

International Classification:

C02F 102
C02F 122
C05F 900

US Classification:

71 11

Abstract:

The present invention provides a waste treatment process and device thereof which can reduce the size and weight of organic waste by decomposing the waste to powder form and bacteria free substance that may be used as a kind of fertilizer for plants. The waste is first frozen by liquefied nitrogen in a cooling chamber to a temperature less than -200. degree. F. , wherein during this freezing procedure, the gas generated from the waste must be removed from the cooling chamber. Then, the frozen nitrogen is immediately transferred to a heated chamber having a temperature of at least 160. degree. F. but not exceed 200. degree. F. During this heating procedure, the water content of the waste is sucked out of the heated chamber, so that the waste is decomposed to form the bacteria free powder.