Thomas D Christian

US Patent:

20230058852, Feb 23, 2023

Filed:

Mar 9, 2022

Appl. No.:

17/690920

Inventors:

- Guilford CT, US
Mohammad Wadud Bhuiya - Olivette MO, US
Manjula Pandey - Guilford CT, US
Jeremy Lackey - Foster City CA, US
Jonathan M. Rothberg - Miami Beach FL, US
Thomas Christian - Killingworth CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

C12N 9/12
C12Q 1/6869
C12P 19/34
C12N 15/52

Abstract:

Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes. In some aspects, methods of using such polymerizing enzymes to synthesize a nucleic acid molecule or to sequence a nucleic acid template are provided.

US Patent:

20200219590, Jul 9, 2020

Filed:

Nov 15, 2019

Appl. No.:

16/686028

Inventors:

- Guilford CT, US
Jeremy Lackey - Foster City CA, US
Thomas Christian - Killingworth CT, US
Roger Nani - Madison CT, US
David Dodd - Guilford CT, US
Kathren Croce - West Haven CT, US
Alexander Goryaynov - New Haven CT, US
Jonathan M. Rothberg - Guilford CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G16B 50/30
G16B 25/10
G16B 40/00
C12Q 1/6806

Abstract:

Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

US Patent:

20200209249, Jul 2, 2020

Filed:

Dec 10, 2019

Appl. No.:

16/709103

Inventors:

- Guilford CT, US
Jeremy Lackey - Foster City CA, US
Thomas Christian - Killingworth CT, US
Roger Nani - Madison CT, US
David Dodd - Guilford CT, US
Kathren Croce - West Haven CT, US
Alexander Goryaynov - New Haven CT, US
Jonathan M. Rothberg - Guilford CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 33/58
G01N 33/68
G01N 1/28
G01N 21/64

Abstract:

Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

US Patent:

20200209253, Jul 2, 2020

Filed:

Dec 10, 2019

Appl. No.:

16/708956

Inventors:

- Guilford CT, US
Jeremy Lackey - Foster City CA, US
Thomas Christian - Killingworth CT, US
Roger Nani - Madison CT, US
David Dodd - Guilford CT, US
Kathren Croce - West Haven CT, US
Alexander Goryaynov - New Haven CT, US
Jonathan M. Rothberg - Guilford CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 33/68
G01N 33/58
G16B 30/00

Abstract:

Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

US Patent:

20200209254, Jul 2, 2020

Filed:

Dec 10, 2019

Appl. No.:

16/708989

Inventors:

- Guilford CT, US
Jeremy Lackey - Foster City CA, US
Thomas Christian - Killingworth CT, US
Roger Nani - Madison CT, US
David Dodd - Guilford CT, US
Kathren Croce - West Haven CT, US
Alexander Goryaynov - New Haven CT, US
Jonathan M. Rothberg - Guilford CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 33/68

Abstract:

Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

US Patent:

20200209255, Jul 2, 2020

Filed:

Dec 10, 2019

Appl. No.:

16/709024

Inventors:

- Guilford CT, US
Jeremy Lackey - Foster City CA, US
Thomas Christian - Killingworth CT, US
Roger Nani - Madison CT, US
David Dodd - Guilford CT, US
Kathren Croce - West Haven CT, US
Alexander Goryaynov - New Haven CT, US
Jonathan M. Rothberg - Guilford CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 33/68
C07K 14/47

Abstract:

Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

US Patent:

20200209256, Jul 2, 2020

Filed:

Dec 10, 2019

Appl. No.:

16/709052

Inventors:

- Guilford CT, US
Jeremy Lackey - Foster City CA, US
Thomas Christian - Killingworth CT, US
Roger Nani - Madison CT, US
David Dodd - Guilford CT, US
Kathren Croce - West Haven CT, US
Alexander Goryaynov - New Haven CT, US
Jonathan M. Rothberg - Guilford CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 33/68
G01N 33/58
G16B 30/00

Abstract:

Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

US Patent:

20200209257, Jul 2, 2020

Filed:

Dec 10, 2019

Appl. No.:

16/709077

Inventors:

- Guilford CT, US
Jeremy Lackey - Foster City CA, US
Thomas Christian - Killingworth CT, US
Roger Nani - Madison CT, US
David Dodd - Guilford CT, US
Kathren Croce - West Haven CT, US
Alexander Goryaynov - New Haven CT, US
Jonathan M. Rothberg - Guilford CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 33/68
G01N 33/58
C07K 19/00

Abstract:

Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.