Thomas M Dunlap

US Patent:

8382987, Feb 26, 2013

Filed:

Aug 19, 2008

Appl. No.:

12/194371

Inventors:

Alessandra Luchini - Fairfax VA, US
Lance Liotta - Bethesda MD, US
Emanuel Petricoin - Gainesville VA, US
Barney Bishop - Annandale VA, US
Francesco Meani - Fairfax VA, US
Claudia Fredolini - Bristow VA, US
Thomas M Dunlap - Round Hill VA, US
Alexis Patanarut - Burke VA, US

International Classification:

B01D 39/16

US Classification:

210635

Abstract:

Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.

US Patent:

20140045274, Feb 13, 2014

Filed:

Feb 25, 2013

Appl. No.:

13/776631

Inventors:

Alessandra Luchini Kunkel - Burke VA, US
Lance Liotta - Bethesda MD, US
Emanuel Petricoin - Gainsville VA, US
Barney Bishop - Annandale VA, US
Francesco Meani - Lugano, CH
Claudia Fredolini - Stockholm, SE
Thomas M. Dunlap - Round Hill VA, US
Alexis Patanarut - Burke VA, US

International Classification:

G01N 1/40

US Classification:

436178

Abstract:

Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.