Thomas C Grove

US Patent:

20060148103, Jul 6, 2006

Filed:

Dec 30, 2004

Appl. No.:

11/027422

Inventors:

Stephan Thompson - El Segundo CA, US
Thomas Grove - Manhattan Beach CA, US

International Classification:

G01N 33/551

US Classification:

436524000

Abstract:

Biological assay systems with enhanced sensitivity may employ waveguides. Quantum dots, which are inorganic fluorescent markers, may be used as markers that will indicate a presence of amount of one or more target molecules (e.g., analytes) in a sample. Multiple markers may be bound to each target molecule or a corresponding competitive molecule to provide a more intense signal from each such molecule and, thus, increased sensitivity. Such multiple binding may be effected by cascading techniques, by binding markers to multiple sites on a target molecule or corresponding competitive molecule, or otherwise.

US Patent:

20060216765, Sep 28, 2006

Filed:

Mar 25, 2005

Appl. No.:

11/091017

Inventors:

Thomas Grove - Manhattan Beach CA, US
Stephan Thompson - El Segundo CA, US
Donald Wong - Granada Hills CA, US

International Classification:

G01N 33/554
C12Q 1/04

US Classification:

435007320, 435034000

Abstract:

A method for detecting microorganisms includes obtaining a sample from a source of interest and applying the sample to a selective growth medium to permit any microorganisms of interest in the sample to grow. Any microorganisms that have grown are harvested. An immunoassay is then conducted to detect the microorganism of interest, if any, with a high degree of sensitivity and specificity. A system that may be used to grow, harvest, and detect a microorganism of interest includes a growth plate, or dish, a lavage solution, a lavage apparatus, and an assay apparatus. The dish may include a vessel with multiple sections, at least one of which is used to grow microorganisms of interest, and another of which is configured to receive and contain harvested microorganisms of interest.

US Patent:

20070141562, Jun 21, 2007

Filed:

Dec 8, 2006

Appl. No.:

11/636093

Inventors:

Thomas H. Grove - Manhattan Beach CA, US

International Classification:

C12Q 1/70
C12Q 1/04
B32B 27/04
C12M 1/34
C12M 3/00

US Classification:

435 5, 435 34, 4352871, 442123

Abstract:

This invention discloses an apparatus and methods for high yield microbial surface sampling. The microbial sampling techniques in which a sample is obtained from an environmental or biological surface using a microfiber material in the form of microfiber devices, wipes, or swabs.

US Patent:

20110184254, Jul 28, 2011

Filed:

Nov 22, 2010

Appl. No.:

12/952017

Inventors:

Thomas H. Grove - Manhattan Beach CA, US
Elisabeth Inman Laderman - Fullerton CA, US

International Classification:

A61B 5/00
G01N 33/53
C40B 30/04
B01J 19/00
C40B 40/10

US Classification:

600301, 436501, 506 9, 422 69, 506 18

Abstract:

The present invention concerns the identification of biomarkers and groups or combinations of biomarkers that can be used for non-invasive diagnosis of intra-amniotic infection, and diagnostic assays using such biomarkers.

US Patent:

20160077101, Mar 17, 2016

Filed:

Sep 9, 2015

Appl. No.:

14/849386

Inventors:

- Marlborough MA, US
Thomas H. Grove - Manhattan Beach CA, US

International Classification:

G01N 33/68

Abstract:

The present invention concerns the identification of biomarkers and groups or combinations of biomarkers that can be used for non-invasive diagnosis of intra-amniotic infection, and diagnostic assays using such biomarkers.

US Patent:

20140154714, Jun 5, 2014

Filed:

Feb 7, 2014

Appl. No.:

14/175476

Inventors:

- Marlborough MA, US
Thomas H. Grove - Manhattan Beach CA, US

Assignee:

Hologic, Inc. - Marlborough MA

International Classification:

G01N 33/569

US Classification:

435 792, 435 71

Abstract:

The present invention concerns the identification of biomarkers and groups or combinations of biomarkers that can be used for non-invasive diagnosis of intra-amniotic infection, and diagnostic assays using such biomarkers.