Thomas R Julian

US Patent:

48512265, Jul 25, 1989

Filed:

Jun 30, 1988

Appl. No.:

7/214265

Inventors:

Thomas N. Julian - Horsham PA
Galen W. Radebaugh - Maple Glen PA

Assignee:

McNeil Consumer Products Company - Fort Washington PA

International Classification:

A61K 932

US Classification:

424441

Abstract:

Chewable medicament tablets are made from coated granules of medicament wherein the coating on said granules comprises a blend of cellulose acetate or cellulose acetate butyrate and polyvinyl pyrrolidone.

US Patent:

54627478, Oct 31, 1995

Filed:

Jan 17, 1995

Appl. No.:

8/373914

Inventors:

Galen W. Radebaugh - Maple Glen PA
Thomas N. Julian - Horsham PA
Robert Glinecke - Glenside PA

Assignee:

McNeil-PPC, Inc. - Milltown NJ

International Classification:

A61K 922
A61K 924
A61K 926

US Classification:

424465

Abstract:

A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e. g. microcrystalline cellulose, an erosion promoter, e. g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e. g. magnesium stearate and glidant, e. g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.

US Patent:

52001938, Apr 6, 1993

Filed:

Oct 22, 1990

Appl. No.:

7/600279

Inventors:

Galen W. Radebaugh - Maple Glen PA
Thomas N. Julian - Horsham PA
Robert Glinecke - Glenside PA

Assignee:

McNeilab, Inc. - Spring House PA

International Classification:

A61R 972

US Classification:

424468

Abstract:

A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e. g. microcrystalline cellulose, an erosion promoter, e. g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e. g. magnesium stearate and glidant, e. g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.

US Patent:

48063592, Feb 21, 1989

Filed:

Apr 22, 1987

Appl. No.:

7/041164

Inventors:

Galen W. Radebaugh - Maple Glen PA
Robert Glinecke - Glenside PA
Thomas N. Julian - Horsham PA

Assignee:

McNeilab, Inc. - Spring House PA

International Classification:

A61K 926

US Classification:

424470

Abstract:

An ibuprofen-sustained release tablet or tablet layer is formed by making a wet granulation using providone (PVP) in alcohol as the granulating fluid which is mixed with ibuprofen, ethylcellulose, a wicking agent e. g. microcrystalline cellulose, an erosion promoter e. g. pregelatinized starch, then drying and milling the granulation and blending with dry powdered erosion promotor, wicking agent, lubricant e. g. magnesium stearate and glidant e. g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the ibuprofen.