Thomas P Mathers

US Patent:

8097005, Jan 17, 2012

Filed:

Aug 25, 2003

Appl. No.:

10/647657

Inventors:

William Cohn - Chestnut Hill MA, US
Thomas P. Mathers - Newbury MA, US

Assignee:

Beth Israel Deaconess Medical Center - Boston MA
Teleflex Incorporated - Limerick PA

International Classification:

A61B 17/04

US Classification:

606148, 606228

Abstract:

A suture system includes a plurality of double-stranded needles connected in sequence with a single-stranded needle at each end. The double-stranded suture needles incorporates two suture strands into a single needle. The suture system of the present invention facilitates the implantation of valve prostheses.

US Patent:

8546532, Oct 1, 2013

Filed:

Apr 17, 2009

Appl. No.:

12/386493

Inventors:

Dustan Bonnin - Belmont MA, US
Eric Zanelli - Sudbury MA, US
Thomas Mathers - Boston MA, US

Assignee:

Declion Pharmaceuticals, Inc. - Boxford MA

International Classification:

A61K 38/00
A61K 51/00

US Classification:

530334, 530333, 530300, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530350

Abstract:

The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

US Patent:

20110129497, Jun 2, 2011

Filed:

Oct 16, 2008

Appl. No.:

12/288345

Inventors:

Dustan Bonnin - Belmont MA, US
Eric Zanelli - Sudbury MA, US
Jeff Krieger - Newtonville MA, US
Thomas Mathers - Boston MA, US

Assignee:

Peptimmune, Inc. - Cambridge MA

International Classification:

A61K 39/145
C07K 1/107
A61K 39/00
A61K 39/12
A61K 39/02
A61P 31/16
A61P 31/12
A61P 31/04
A61P 33/00
A61P 37/04

US Classification:

4242091, 530324, 530409, 4241841, 4242041, 4242341, 4242651

Abstract:

The instant invention comprises a process of preparing a composition comprising directed sequence polymer (DSP) mixtures that act as epitopes and useful as vaccines, such DSP synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use as a vaccine, preferably for infectious agents that are immune evasive.

US Patent:

20120130405, May 24, 2012

Filed:

Jan 13, 2012

Appl. No.:

13/350175

Inventors:

William Cohn - Chestnut Hill MA, US
Thomas P. Mathers - Newburyport MA, US

International Classification:

A61B 17/04

US Classification:

606147

Abstract:

A suture system includes a plurality of double-stranded needles connected in sequence with a single-stranded needle at each end. The double-stranded suture needles incorporates two suture strands into a single needle. The suture system of the present invention facilitates the implantation of valve prostheses.

US Patent:

6610071, Aug 26, 2003

Filed:

Jul 26, 1999

Appl. No.:

09/360709

Inventors:

William Cohn - Chestnut Hill MA
Thomas P. Mathers - Newbury MA

Assignee:

Beth Israel Deaconess Medical Center - Boston MA
Genzyme Corporation - Cambridge MA

International Classification:

A61B 1704

US Classification:

606148, 606228, 623 211

Abstract:

A suture system includes a plurality of double-stranded needles connected in sequence with a single-stranded needle at each end. The double-stranded suture needles incorporates two suture strands into a single needle. The suture system of the present invention facilitates the implantation of valve prostheses.

US Patent:

20140271614, Sep 18, 2014

Filed:

Sep 12, 2013

Appl. No.:

14/025223

Inventors:

- Boxford MA, US
Eric Zanelli - Sudbury MA, US
Thomas P. Mathers - Boxford MA, US

Assignee:

DECLION PHARMACEUTICALS, INC. - Boxford MA

International Classification:

C07K 1/04
C07K 16/18

US Classification:

4241301, 435 704, 506 30

Abstract:

The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.