Thomas J O'Brien

US Patent:

20020081611, Jun 27, 2002

Filed:

Jul 24, 2001

Appl. No.:

09/911935

Inventors:

Thomas O'Brien - Drexel Hill PA, US
Yong Guo - Drexel Hill PA, US

Assignee:

Lankenau Medical Research Center - Wynnewood PA

International Classification:

C12Q001/68
C07H021/04

US Classification:

435/006000, 536/024300

Abstract:

The invention includes kits and methods for assessing the susceptibility of a mammal such as a human for carcinogenesis. The methods comprise determining whether the mammal comprises a certain allele of the mammal's odc gene. The methods include use of a probe which binds specifically with a portion of one allele of the odc gene and which comprises a fluorescent label and a fluorescence quencher. The methods also include use of such a probe and a polymerase enzyme for amplifying a portion of the odc gene, the polymerase having exonuclease activity whereby the probe can be nucleolytically degraded.

US Patent:

20040185195, Sep 23, 2004

Filed:

Aug 5, 2003

Appl. No.:

10/635148

Inventors:

Christopher Anderson - Wilmington DE, US
Sheila Kennedy - Boston MA, US
Thomas O'Brien - Wilmington DE, US
Marie O'Regan - Santa Barbara CA, US
C. Smith - Vienna WV, US

International Classification:

E06B003/24

US Classification:

428/034000, 428/049000

Abstract:

This invention relates to laminated glass, structural glass blocks and structural plyglass as carrying cases for solid state lighting, sensors, energy generation and storage devices and other electronics that are contained within the transparent non-glass interlayers or air cavities of the laminated glass, structural glass blocks and structural plyglass.

US Patent:

20050233125, Oct 20, 2005

Filed:

Aug 6, 2003

Appl. No.:

10/521505

Inventors:

Christopher Anderson - Wilmington DE, US
Sheila Kennedy - Boston MA, US
Thomas O'Brien - Wilmington DE, US
Marie O'regan - Santa Barbara CA, US
C. Smith - Vienna WV, US

International Classification:

B32B001/00

US Classification:

428221000, 340693500

Abstract:

This invention relates to laminated glass, structural glass blocks and structural plyglass as carrying cases for solid state lighting sensors, energy generation and storage devices and other electronics that are contained within the transparent non-glass interlayers or air cavities of the laminated glass, structural glass blocks and structural plyglass.

US Patent:

20060164002, Jul 27, 2006

Filed:

Aug 6, 2003

Appl. No.:

10/521501

Inventors:

Thomas O'Brien - Wilmington DE, US
Marie O'Regan - Santa Barbara CA, US
C. Haas - Wilmington DE, US

International Classification:

B32B 27/00
H01L 33/00

US Classification:

313498000, 428411100, 428702000

Abstract:

This invention relates to laminated polymer as a host for solid state lighting, sensors, energy generation and storage devices and other electronics that are contained within the transparent non-glass interlayers or air cavities of the laminated polymer.

US Patent:

20110259763, Oct 27, 2011

Filed:

Sep 7, 2010

Appl. No.:

12/807478

Inventors:

Thomas O'Brien - Phoenixville PA, US

International Classification:

B44D 3/02

US Classification:

206 17

Abstract:

An artist palette is disclosed comprising a three-point anchor system for improved comfort and ease of use. The system comprises a first anchor point including a thumb resting surface and a grasping surface, a second anchor point including a forearm resting surface forming a line with the first anchor point parallel to the forearm, and a third anchor point including a torso resting surface forming a triangle together with the first anchor point and the second anchor point. Optionally, the grasping surface rests inside the palette and either one or more of the forearm resting surface and the torso resting surface includes a concave arc curving toward the first anchor point.

US Patent:

20130164328, Jun 27, 2013

Filed:

Feb 20, 2013

Appl. No.:

13/771799

Inventors:

Lankenau Institute For Medical Research - Wynnewood PA, US
Thomas G. O'Brien - Wynnewood PA, US

Assignee:

Lankenau Institute For Medical Research - Wynnewood PA
Aminex Therapeutics - Kenmore WA

International Classification:

A61K 39/21
A61K 45/00
A61K 39/02
A61K 39/00
A61K 39/145

US Classification:

4242081, 4241841, 4242091, 4242341

Abstract:

This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction. This therapeutic approach is equally applicable to disease states whereby immune system suppression by polyamines has been demonstrated including; bacterial infections, parasitic infections including malaria and typanosomiasis, viral infections, peptic ulcers and gastric cancer due to infection together with prevention of pregnancy. With a small molecule drug, used in combination with DFMO, the pharmacological manipulation of polyamine levels for therapeutic benefit in various disease states is possible.

US Patent:

62775812, Aug 21, 2001

Filed:

Mar 1, 2000

Appl. No.:

9/516357

Inventors:

Thomas G. O'Brien - Drexel Hill PA
Yong Jun Guo - Drexel Hill PA

Assignee:

Lankenau Medical Research Center - Wynnewood PA

International Classification:

C12Q 168
C12P 1934
C12N 1511
C07H 2104

US Classification:

435 6

Abstract:

The invention includes kits and methods for assessing the susceptibility of a mammal such as a human for carcinogenesis. The methods comprise determining whether the mammal comprises a certain allele of the mammal's odc gene. The methods include use of a probe which binds specifically with a portion of one allele of the odc gene and which comprises a fluorescent label and a fluorescence quencher. The methods also include use of such a probe and a polymerase enzyme for amplifying a portion of the odc gene, the polymerase having exonuclease activity whereby the probe can be nucleolytically degraded.

US Patent:

45869936, May 6, 1986

Filed:

May 31, 1985

Appl. No.:

6/739730

Inventors:

Thomas F. O'Brien - Media PA

Assignee:

Stearns Catalytic World Corporation - Denver CO

International Classification:

C25B 116

US Classification:

204 98

Abstract:

Method of addition of calcium ions to salt-depleted brine prior to resaturation, wherein the concentration of sulfate impurity is controlled. The invention relates to a process for the electrolysis of aqueous alkali metal chloride solutions to produce chlorine and high purity alkali metal hydroxide solutions.