Thomas Richard O'Brien

US Patent:

7618783, Nov 17, 2009

Filed:

Apr 30, 2001

Appl. No.:

09/844281

Inventors:

Beverly Lynn Mangold - Rockville MD, US
Jennifer Lynn Aldrich - Silver Spring MD, US
Thomas W. O'Brien - Fairfax VA, US

Assignee:

Tetracore, Inc. - Rockville MD

International Classification:

G01N 33/53

US Classification:

435 71, 435 4, 435 72, 435 732, 435 772, 435975, 5303871, 5303881, 5303882, 5303884, 4241641

Abstract:

The present invention is directed to diagnostic tools and therapies using antibodies to Specifically, the present invention is directed to a -specific monoclonal antibody that binds to the EA1 antigen (corresponding to the eag gene) of the S-layer (surface layer) of spores. This monoclonal antibody may be used in a variety of applications, including to specifically detect and diagnose Preferably, antibodies are monoclonal and bind to a surface protein, such as EA1 protein, on the spores of and not to spores of either or Antibodies can be incorporated into detection kits using, for example, colloidal particle based lateral flow detection system. Such detection kits can distinguish anthrax spores from non-pathogenic varieties of spores. In addition, the invention is directed to EA1 antigen and pharmaceuticals such as vaccines that can be used as therapeutics and to develop improved antibodies and detection methods.

US Patent:

20020081611, Jun 27, 2002

Filed:

Jul 24, 2001

Appl. No.:

09/911935

Inventors:

Thomas O'Brien - Drexel Hill PA, US
Yong Guo - Drexel Hill PA, US

Assignee:

Lankenau Medical Research Center - Wynnewood PA

International Classification:

C12Q001/68
C07H021/04

US Classification:

435/006000, 536/024300

Abstract:

The invention includes kits and methods for assessing the susceptibility of a mammal such as a human for carcinogenesis. The methods comprise determining whether the mammal comprises a certain allele of the mammal's odc gene. The methods include use of a probe which binds specifically with a portion of one allele of the odc gene and which comprises a fluorescent label and a fluorescence quencher. The methods also include use of such a probe and a polymerase enzyme for amplifying a portion of the odc gene, the polymerase having exonuclease activity whereby the probe can be nucleolytically degraded.

US Patent:

20040185195, Sep 23, 2004

Filed:

Aug 5, 2003

Appl. No.:

10/635148

Inventors:

Christopher Anderson - Wilmington DE, US
Sheila Kennedy - Boston MA, US
Thomas O'Brien - Wilmington DE, US
Marie O'Regan - Santa Barbara CA, US
C. Smith - Vienna WV, US

International Classification:

E06B003/24

US Classification:

428/034000, 428/049000

Abstract:

This invention relates to laminated glass, structural glass blocks and structural plyglass as carrying cases for solid state lighting, sensors, energy generation and storage devices and other electronics that are contained within the transparent non-glass interlayers or air cavities of the laminated glass, structural glass blocks and structural plyglass.

US Patent:

20050233125, Oct 20, 2005

Filed:

Aug 6, 2003

Appl. No.:

10/521505

Inventors:

Christopher Anderson - Wilmington DE, US
Sheila Kennedy - Boston MA, US
Thomas O'Brien - Wilmington DE, US
Marie O'regan - Santa Barbara CA, US
C. Smith - Vienna WV, US

International Classification:

B32B001/00

US Classification:

428221000, 340693500

Abstract:

This invention relates to laminated glass, structural glass blocks and structural plyglass as carrying cases for solid state lighting sensors, energy generation and storage devices and other electronics that are contained within the transparent non-glass interlayers or air cavities of the laminated glass, structural glass blocks and structural plyglass.

US Patent:

20060115908, Jun 1, 2006

Filed:

Nov 10, 2005

Appl. No.:

11/271040

Inventors:

Thomas O'Brien - Fairfax VA, US

Assignee:

TETRACORE, INC. - Rockville MD

International Classification:

G01N 33/551

US Classification:

436524000, 977920000

Abstract:

Air or gas is drawn into a particle impact collector where the air or gas is forced through non-linear passages inside the collector in such a manner that particles or droplets entrained in the air or gas, or contaminant vapors in the air or gas, are retained in and concentrated by the passages. Once retained and concentrated, the contaminants are suspended or dissolved in a liquid collection medium purging the passages, the collection medium containing assay reagents for a multiplexed binding assay. The agitation produced by the flow of gas and liquid through the non-linear passages increases the reaction rate of the assay.

US Patent:

20060164002, Jul 27, 2006

Filed:

Aug 6, 2003

Appl. No.:

10/521501

Inventors:

Thomas O'Brien - Wilmington DE, US
Marie O'Regan - Santa Barbara CA, US
C. Haas - Wilmington DE, US

International Classification:

B32B 27/00
H01L 33/00

US Classification:

313498000, 428411100, 428702000

Abstract:

This invention relates to laminated polymer as a host for solid state lighting, sensors, energy generation and storage devices and other electronics that are contained within the transparent non-glass interlayers or air cavities of the laminated polymer.

US Patent:

20110200614, Aug 18, 2011

Filed:

Nov 16, 2009

Appl. No.:

12/619489

Inventors:

Beverly Lynn Mangold - Rockville MD, US
Jennifer Lynn Aldrich - Silver Spring MD, US
Thomas W. O'Brien - Fairfax VA, US

International Classification:

A61K 39/395
C12N 5/071
G01N 33/569
G01N 33/566
C07K 16/12
C12P 21/08
C07K 14/32
A61K 39/07
A61P 37/04
A61P 31/04

US Classification:

4241641, 435340, 435 71, 436501, 5303884, 435 7021, 5303879, 5303873, 5303895, 530350, 4242461

Abstract:

The present invention is directed to diagnostic tools and therapies using antibodies to . Specifically, the present invention is directed to a -specific monoclonal antibody that binds to the EA1 antigen (corresponding to the eag gene) of the S-layer (surface layer) of spores. This monoclonal antibody may be used in a variety of applications, including to specifically detect and diagnose . Preferably, antibodies are monoclonal and bind to a surface protein, such as EA1 protein, on the spores of , and not to spores of either or . Antibodies can be incorporated into detection kits using, for example, colloidal particle based lateral flow detection system. Such detection kits can distinguish anthrax spores from non-pathogenic varieties of spores. In addition, the invention is directed to EA1 antigen and pharmaceuticals such as vaccines that can be used as therapeutics and to develop improved antibodies and detection methods.

US Patent:

20110259763, Oct 27, 2011

Filed:

Sep 7, 2010

Appl. No.:

12/807478

Inventors:

Thomas O'Brien - Phoenixville PA, US

International Classification:

B44D 3/02

US Classification:

206 17

Abstract:

An artist palette is disclosed comprising a three-point anchor system for improved comfort and ease of use. The system comprises a first anchor point including a thumb resting surface and a grasping surface, a second anchor point including a forearm resting surface forming a line with the first anchor point parallel to the forearm, and a third anchor point including a torso resting surface forming a triangle together with the first anchor point and the second anchor point. Optionally, the grasping surface rests inside the palette and either one or more of the forearm resting surface and the torso resting surface includes a concave arc curving toward the first anchor point.