Thomas C Pochapsky

US Patent:

20020115896, Aug 22, 2002

Filed:

Jul 10, 2001

Appl. No.:

09/902446

Inventors:

Thomas Pochapsky - Arlington MA, US
Christine Hofstetter - Fremont CA, US

International Classification:

C07C017/08
B01J031/00

US Classification:

570/231000, 502/162000

Abstract:

One aspect of the present invention relates to methods of asymmetric synthesis, e.g., asymmetric hydride reductions of carbonyl groups, using a chiral, non-racemic phase transfer catalyst, a helper nucleophile, and a sterically bulky reagent nucleophile, e.g., an alkoxyhydride derived from a sacrificial ketone and a hydride reagent. Moreover, the sterically bulky reagent nucleophile may be generated in situ or prepared in a prior step. Another aspect of the present invention relates to chiral non-racemic phase transfer catalysts, and their use in the subject methods.

US Patent:

20090203644, Aug 13, 2009

Filed:

Oct 24, 2005

Appl. No.:

11/665793

Inventors:

Orrie Friedman - Brookline MA, US
Thomas C. Pochapsky - Arlington MA, US
Julie Yu Wei - Woburn MA, US

Assignee:

GrenPharma LLC - Waltham MA

International Classification:

A61K 31/695
A61P 25/28

US Classification:

514 63

Abstract:

The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including silicon-amino compounds. In some cases, a silicon-amino compound of the invention may be bidentate, tridentate, or otherwise polydentate, and in certain instances, the silicon-amino compound, or a portion thereof, may sequester aluminum or other ions, for example, by electrostatically binding the ions. Further aspects of the invention relate to methods of making and using such compositions of the invention, as well as articles and kits associated with the compositions.