Thomas Pochapsky - Arlington MA, US Christine Hofstetter - Fremont CA, US
International Classification:
C07C017/08 B01J031/00
US Classification:
570/231000, 502/162000
Abstract:
One aspect of the present invention relates to methods of asymmetric synthesis, e.g., asymmetric hydride reductions of carbonyl groups, using a chiral, non-racemic phase transfer catalyst, a helper nucleophile, and a sterically bulky reagent nucleophile, e.g., an alkoxyhydride derived from a sacrificial ketone and a hydride reagent. Moreover, the sterically bulky reagent nucleophile may be generated in situ or prepared in a prior step. Another aspect of the present invention relates to chiral non-racemic phase transfer catalysts, and their use in the subject methods.
Compositions For Treating And/Or Preventing Diseases Characterized By The Presence Of Metal Ions
Orrie Friedman - Brookline MA, US Thomas C. Pochapsky - Arlington MA, US Julie Yu Wei - Woburn MA, US
Assignee:
GrenPharma LLC - Waltham MA
International Classification:
A61K 31/695 A61P 25/28
US Classification:
514 63
Abstract:
The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including silicon-amino compounds. In some cases, a silicon-amino compound of the invention may be bidentate, tridentate, or otherwise polydentate, and in certain instances, the silicon-amino compound, or a portion thereof, may sequester aluminum or other ions, for example, by electrostatically binding the ions. Further aspects of the invention relate to methods of making and using such compositions of the invention, as well as articles and kits associated with the compositions.
Brandeis University
Professor
Conocophillips 1978 - 1980
Analytical Chemist
Combustion Engineering 1976 - 1978
Analytical Chemist
Education:
University of Illinois at Urbana - Champaign 1981 - 1986
Doctorates, Doctor of Philosophy, Philosophy, Organic Chemistry
University of Pittsburgh 1974 - 1977
Bachelors, Bachelor of Science, Chemistry
Skills:
Nmr Biophysics Structural Biology Protein Chemistry Biochemistry Chemistry Molecular Biology Protein Purification Mass Spectrometry Purification Research X Ray Crystallography Teaching Protein Expression Chromatography Spectroscopy Molecular Modeling Chiral Chromatography
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