Thomas J Raife

US Patent:

20050153383, Jul 14, 2005

Filed:

Jul 27, 2001

Appl. No.:

10/333506

Inventors:

Robert Montgomery - Cedarburg WI, US
Thomas Raife - Iowa City IA, US
Sandra Haberichter - Greenfield WI, US

International Classification:

C12Q001/37

US Classification:

435023000

Abstract:

A method of detecting von Willebrand Factor-cleaving protease in a test sample is disclosed. In one embodiment, the method comprises the steps of (a) obtaining a test bodily fluid sample; (b) exposing the test sample to a monomeric von Willebrand Factor fragment, wherein the fragment comprises amino acids 842 and 843, wherein cleavage of the fragment will occur proportional to the amount of protease in the sample; and (c) comparing the cleavage products to a standard curve and determining the amount of von Willebrand Factor-cleaving protease in the test sample.

US Patent:

55831028, Dec 10, 1996

Filed:

Dec 3, 1993

Appl. No.:

8/162462

Inventors:

Steven R. Lentz - Iowa City IA
Thomas J. Raife - Iowa City IA
Donna J. Lager - Iowa City IA

Assignee:

University of Iowa Research Foundation - Oakdale IA

International Classification:

A61K 3816
A61K 3817
C07K 14435
C07K 1447

US Classification:

514 8

Abstract:

The use of human thrombomodulin and acceptable derivatives thereof as an agent for stimulating wound regeneration including epithilial cell differentiation is disclosed.