Thomas C Reynolds

US Patent:

6682141, Jan 27, 2004

Filed:

Sep 14, 2001

Appl. No.:

09/953386

Inventors:

Thomas Leroy Reynolds - Bainbridge Island WA
Brian D. Coughren - Kent WA

Assignee:

The Boeing Company - Seattle WA

International Classification:

B60N 242

US Classification:

2972161, 297480, 296 681

Abstract:

The present invention provides a seat assembly supported by a seat frame that includes a seat cushion, an upwardly extending back cushion, a seat repositioning device, and an actuation mechanism that repositions the seat cushion. In one embodiment, an airbag is disposed beneath a seatpan such that inflation raises a forward portion of both the seatpan and seat cushion. Inflation of the airbag is in response to a sensor detecting the rapid deceleration of the vehicle. The seatpan is attached to each respective armrest of the seat frame at a hinge point that permits the seatpan to rotate upwardly. A seatbelt cinching mechanism is attached to the seatpan such that upward rotation of the seatpan pulls the cinching mechanism around an idler pulley, and thereby increases seatbelt tension. In a second embodiment, an airbag inflates through an opening in the seat cushion and above a forward portion of the seat cushion. In a third embodiment, the airbag is substituted with a gas activated cylinder.

US Patent:

6899184, May 31, 2005

Filed:

Jul 30, 2001

Appl. No.:

09/918221

Inventors:

Thomas L. Reynolds - Bainbridge Island WA, US

Assignee:

The Boeing Company - Chicago IL

International Classification:

A62C003/07

US Classification:

169 62, 169 9, 169 16, 169 60, 169 61, 2441292

Abstract:

A fire suppression system adapted for use in a lavatory of an aircraft. The system includes a water supply coupled to one or more fluid discharge nozzles via one or more fluid flow lines. A pressure source in communication with the fluid flow lines provides pressure to assist in supplying a pressurized flow of fluid through the flow line(s) to the nozzles(s). The fire suppression system creates a spray of water capable of suppressing fires within a waste container area or within the entire lavatory area. Heat sensitive valves enable the system to automatically detect the start of a fire. Furthermore, the system is capable of using the potable water supply of the aircraft or it can be self-contained with its own water supply reservoir. If self-contained, the system includes a pressurized fluid source to assist in supplying water to the discharge nozzle(s).

US Patent:

6989264, Jan 24, 2006

Filed:

Oct 30, 2001

Appl. No.:

10/016767

Inventors:

Edward M. Atkinson - Indianapolis IN, US
Ian L. Aranha - Seattle WA, US
Victor P. Fung - Redmond WA, US
Perry C. Wilkins - Preston WA, US
Ryan K. Takeya - Preston WA, US
Thomas C. Reynolds - Mercer Island WA, US

Assignee:

Targeted Genetics Corporation - Seattle WA

International Classification:

C12N 7/02

US Classification:

435239, 435 41, 435 42, 4353201, 435325

Abstract:

This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i. e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.

US Patent:

6995006, Feb 7, 2006

Filed:

Oct 30, 2001

Appl. No.:

10/020482

Inventors:

Edward M. Atkinson - Seattle WA, US
Victor P. Fung - Redmond WA, US
Perry C. Wilkins - Preston WA, US
Ryan K. Takeya - Lynnwood WA, US
Thomas C. Reynolds - Mercer Island WA, US
Ian L. Aranha - Seattle WA, US

Assignee:

Targeted Genetics Corporation - Seattle WA

International Classification:

C12N 7/02

US Classification:

435239, 4352351, 4353201

Abstract:

This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i. e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.

US Patent:

7721812, May 25, 2010

Filed:

May 2, 2005

Appl. No.:

11/120093

Inventors:

Thomas L Reynolds - Bainbridge Island WA, US

Assignee:

The Boeing Company - Chicago IL

International Classification:

A62C 3/07

US Classification:

169 62, 169 9, 169 16, 169 60, 169 61, 169 37, 2441292, 239 74, 239208, 239303

Abstract:

A fire suppression system adapted for use in a lavatory of an aircraft. The system includes a supply coupled to one or more fluid discharge nozzles via one or more fluid flow lines. A pressure source in communication with the fluid flow lines provides pressure to assist in supplying a pressurized flow of fluid through the flow line(s) to the nozzles(s). Furthermore, the system is capable of using the potable water supply of the aircraft or it can be self-contained with its own water supply reservoir. If self-contained, the system includes a pressurized fluid source to assist in supplying water to the discharge nozzle(s).

US Patent:

20050266567, Dec 1, 2005

Filed:

Jun 28, 2005

Appl. No.:

11/170269

Inventors:

Edward Atkinson - Seattle WA, US
Victor Fung - Redmond WA, US
Perry Wilkins - Preston WA, US
Ryan Takeya - Lynnwood WA, US
Thomas Reynolds - Mercer Island WA, US
Ian Aranha - Seattle WA, US

International Classification:

A61K048/00
C12N015/861
C12N007/00

US Classification:

435456000, 435235100, 435457000

Abstract:

This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.

US Patent:

20080206812, Aug 28, 2008

Filed:

Aug 8, 2007

Appl. No.:

11/891195

Inventors:

Edward M. Atkinson - Seattle IN, US
Victor P. Fung - Redmond WA, US
Perry C. Wilkins - Preston WA, US
Ryan K. Takeya - Lynnwood WA, US
Thomas C. Reynolds - Mercer Island WA, US
Ian L. Aranha - Seattle WA, US

International Classification:

C12P 21/04
C07K 1/16
C12N 7/02
C07K 1/18

US Classification:

435 691, 530417, 435239, 530416

Abstract:

This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.

US Patent:

20100248355, Sep 30, 2010

Filed:

Mar 30, 2010

Appl. No.:

12/750570

Inventors:

Edward M. ATKINSON - Indianapolis IN, US
Victor P. Fung - Redmond WA, US
Perry C. Wilkins - Preston WA, US
Ryan K. Takeya - Preston WA, US
Thomas C. Reynolds - Mercer Island WA, US
Ian L. Aranha - Seattle WA, US

International Classification:

C12N 15/63

US Classification:

4353201

Abstract:

This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.