Thomas J Richard

US Patent:

20070078057, Apr 5, 2007

Filed:

Sep 7, 2006

Appl. No.:

11/517004

Inventors:

Keith Rowley - Madison WI, US
Mark Trimmer - Mazomarie WI, US
Thomas Richard - Sunset Hills MO, US
Clara Leung - Madison WI, US

International Classification:

A01N 57/18
A01N 25/04
A01N 43/04
A01N 43/40
A01N 25/16
A01N 65/00

US Classification:

504206000, 504365000, 514028000, 514338000, 514341000, 514065000

Abstract:

The present invention provides a storage stable microemulsion formulation for modified lecithin as well as other materials. For modified lecithin, the microemulsion contains at least one metal chelate complex, at least one surfactant such as an anionic surfactant, modified lecithin, water, and optionally at least one alcohol. For other materials, the microemulsion contains all above plus one or more other materials wherein modified lecithin can be replaced by unmodified lecithin. Further provided are methods of making and using the above microemulsions.

US Patent:

53043251, Apr 19, 1994

Filed:

Nov 13, 1991

Appl. No.:

7/791420

Inventors:

Robert J. Kaufman - University City MO
Thomas J. Richard - University City MO

Assignee:

HemaGen/PFC - St. Louis MO

International Classification:

B01J 1300
A61K 9107

US Classification:

252312

Abstract:

Oil and water emulsions containing alkylphosphoryl choline or alkylglycerophosphoryl choline surfactants are disclosed. The surfactants have the following general structures: ##STR1## In the above general structures, R. sub. 1, R. sub. 2 or R. sub. 3 is alkyl, alkenyl, fluoroalkyl and alkenyl; and PC is the phosphoryl choline. The emulsions are useful as oxygen transport agents, artificial bloods or red blood cell substitutes.

US Patent:

54079624, Apr 18, 1995

Filed:

Feb 3, 1994

Appl. No.:

8/191517

Inventors:

Robert J. Kaufman - University City MO
Thomas J. Richard - University City MO

Assignee:

HemaGen/PFC - St. Louis MO

International Classification:

A61K 31035
A61K 3102
A61K 31685

US Classification:

514744

Abstract:

Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.

US Patent:

57705852, Jun 23, 1998

Filed:

May 8, 1995

Appl. No.:

8/438098

Inventors:

Robert J. Kaufman - University City MO
Thomas J. Richard - University City MO
Richard A. Stephens - St. Louis MO
Thomas H. Goodin - Manchester MO
John S. Allen - St. Louis MO
Tony E. Layton - Godfrey IL

International Classification:

A61K 31685

US Classification:

514 78

Abstract:

This invention is directed to a homogenous water-in-perfluorochemical stable liquid dispersion for acceptable therapeutic administration of a drug to the lung of an animal. The dispersion includes a perfluorochemical liquid, water, surfactant and drug, wherein the water is homogeneously dispersed in the perfluorochemical to form a stable water-in-perfluorochemical liquid dispersion. The perfluorochemical constitutes greater than 50% by volume of the dispersion, and the drug is contained in the dispersion in an effective therapeutic amount. The invention further includes a method of delivering a drug to the lung of an animal. This aspect of the invention includes administering a stable homogenous water-in-perfluorochemical liquid dispersion to the animal lung or a section thereof. If desired, the method may further include delivering a breathable gas to the lung with a mechanical ventilator during the administration.

US Patent:

48104264, Mar 7, 1989

Filed:

Jan 28, 1986

Appl. No.:

6/823178

Inventors:

Donald L. Fields - St. Louis MO
Len F. Lee - St. Charles MO
Thomas J. Richard - University City MO

Assignee:

Monsanto Company - St. Louis MO

International Classification:

C07F 938

US Classification:

2605025F

Abstract:

Hydrolysis of N-phosphonomethyl-2-oxazolidone and separation of the carbon dioxide co-product prior to oxidation of the hydrolyzate to glyphosate results in a process of significantly increased efficiency over the previously described processes.

US Patent:

54203597, May 30, 1995

Filed:

Oct 7, 1993

Appl. No.:

8/132787

Inventors:

George G. I. Moore - Afton MN
Richard M. Flynn - Mahtomedi MN
Robert J. Kaufman - University City MO
Thomas J. Richard - University City MO

Assignee:

Minnesota Mining and Manufacturing Company - St. Paul MN
HemaGen/PFC - St. Louis MO

International Classification:

C07C 4312

US Classification:

568684

Abstract:

Normally liquid chlorofluoroether compositions consisting or consisting essentially of one or a selected mixture of perhalogenated chlorofluoroether compounds are provided by direct fluorination of the corresponding chloroether or chlorofluoroether precursors. The compositions are useful, for example, as heat transfer agents, blood substitutes, and solvents.

US Patent:

55714986, Nov 5, 1996

Filed:

Jun 2, 1994

Appl. No.:

8/252830

Inventors:

William P. Cacheris - Florissant MO
Robert J. Kaufman - University City MO
Thomas J. Richard - University City MO
Raymond C. Grabiak - Maryland Heights MO

Assignee:

HemaGen/PFC - St. Louis MO

International Classification:

A61B 5055

US Classification:

424 9365

Abstract:

Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic chelator having a C. sub. 10 -C. sub. 30 unsaturated aliphatic group. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI.

US Patent:

56163304, Apr 1, 1997

Filed:

Jul 19, 1994

Appl. No.:

8/276899

Inventors:

Robert J. Kaufman - University City MO
Thomas J. Richard - University City MO
Ralph W. Fuhrhop - St. Louis MO

Assignee:

HemaGen/PFC - St. Louis MO

International Classification:

A61K 9107
A61K 31235
B01J 1300

US Classification:

424400

Abstract:

This invention is directed to a composition of a taxine in a stable oil-in-water emulsion for intravenous administration. The invention also relates to a method for incorporating a taxine into an oil and making a stable oil-in-water emulsion. The composition includes a taxine, an oil, water and a surfactant. In a preferred embodiment, the taxine is taxol, the oil is safflower oil and the surfactant is lecithin, The taxine is incorporated into the oil by dissolving the taxine in a solution of an oil and a taxine co-solvent, such as isopropanol, for example. The co-solvent then is removed to form a solution of the taxine in oil. This solution may be dispersed in water with a surfactant to form a stable oil-in-water emulsion for intravenous administration.